Dietary lipids and gene expression
Dietary lipids and gene expression
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DOI：
10.1042/bst0320999
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发表时间：
2004-12-01
影响因子：
3.9
通讯作者：
Roche, HM
中科院分区：
文献类型：
--
作者：
Roche, HM
营养是一个关键的环境因素，特别是参与了几种多基因，饮食相关疾病的发病机制和进展。营养基因组学是指营养和人类基因组之间的相互作用。膳食脂肪酸与多种营养敏感转录因子相互作用。这解释了与改变膳食脂肪酸组成相关的一些健康影响的分子基础。代谢综合征是一种非常常见的疾病，其特征在于胰岛素抵抗、腹部肥胖、血脂异常和高血压。它通常先于2型糖尿病，并与心血管疾病的风险更大有关。有证据表明，营养源性代谢应激源和促炎信号之间的相互作用在胰岛素抵抗的病因学和代谢综合征的发展中起着重要作用。本文将讨论几种营养敏感的转录因子之间的相互作用，包括SREBP（固醇调节元件结合蛋白）和NF κ B（核因子κ B），证明这种相互作用如何改变饮食脂肪酸干预。
Nutrition is a key environmental factor that is particularly involved in the pathogenesis and progression of several polygenic, diet-related diseases. Nutrigenomics refers to the interaction between nutrition and the human genome. Dietary fatty acids interact with multiple nutrient-sensitive transcription factors. This explains the molecular basis of some of the health effects associated with altered dietary fatty acid composition. The metabolic syndrome is a very common condition, characterized by insulin resistance, abdominal obesity, dyslipidaemia and hypertension. It often precedes Type 2 diabetes mellitus, and is associated with a greater risk of cardiovascular disease. Several lines of evidence suggest that the interaction between nutrient-derived metabolic stressors and pro-inflammatory signals play an important role in the aetiology of insulin resistance and the development of the metabolic syndrome. This paper will address the interaction between several nutrient-sensitive transcription factors, including SREBP (sterol-regulatory-element-binding protein) and NFkappaB (nuclear factor kappaB), demonstrating how this interaction may be altered with dietary fatty acid interventions.