The common link between functional somatic syndromes may be central sensitisation
The common link between functional somatic syndromes may be central sensitisation
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DOI：
10.1016/j.jpsychores.2015.01.003
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发表时间：
2015-03-01
影响因子：
4.7
通讯作者：
White, Peter D.
中科院分区：
文献类型：
--
作者：
Bourke, Julius H.;Langford, Richard M.;White, Peter D.
目的：功能性躯体综合征是一种常见的致残性疾病，包括慢性疼痛，可能与中枢神经系统致敏有关。在这里，我们解决的概念，中央敏化作为生理基础的功能性躯体syndromes.Methods：一个叙事性的回顾目前的文献对中央敏化和生理研究的功能性躯体syndromes.Results：中央敏化可能是一个共同的神经生理过程，能够解释非疼痛以及疼痛症状，在这些疾病。此外，中央敏化可能代表一个endphenotypic脆弱性的发展，这些综合征，可能解释了为什么他们cluster together.Conclusions：需要进一步的研究，以验证这些发现，包括前瞻性研究和标准化相结合的调查方法，在中央敏化功能性躯体综合征的研究。反过来，这可能会导致新的解释机制和治疗正在评估。我们的结论增加了关于这些综合征命名的争论，但重要的是也为我们的患者提供了解释。(C)2015 Elsevier Inc. All rights reserved.
Objectives: Functional somatic syndromes are common and disabling conditions that all include chronic pain, and which may be related to central nervous system sensitisation. Here, we address the concept of central sensitisation as a physiological basis for the functional somatic syndromes.Methods: A narrative review of the current literature on central sensitisation and physiological studies in the functional somatic syndromes.Results: Central sensitisation may be a common neurophysiological process that is able to explain non-painful as well as painful symptoms in these disorders. Furthermore, central sensitisation may represent an endophenotypic vulnerability to the development of these syndromes that potentially explains why they cluster together.Conclusions: Further research is needed to verify these findings, including prospective studies and the standardisation of combined methods of investigation in the study of central sensitisation in functional somatic syndromes. In turn, this may lead to new explanatory mechanisms and treatments being evaluated. Our conclusions add to the debate over the nomenclature of these syndromes but importantly also provide an explanation for our patients. (C) 2015 Elsevier Inc. All rights reserved.