A phase III study of radiotherapy with and without continuous-infusion fluorouracil as palliation for non-small-cell lung cancer.
A phase III study of radiotherapy with and without continuous-infusion fluorouracil as palliation for non-small-cell lung cancer.
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DOI：
10.1038/bjc.1997.123
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发表时间：
1997
影响因子：
8.8
通讯作者：
Millward, M
中科院分区：
文献类型：
--
作者：
Ball, D;Smith, J;Bishop, J;Olver, I;Davis, S;OBrien, P;Bernshaw, D;Ryan, G;Millward, M
本研究评估了在姑息性胸部放射治疗 (RT) 中添加连续输注氟尿嘧啶对晚期非小细胞肺癌 (NSCLC) 患者症状缓解率和持续时间的影响。 200 名符合条件的 NSCLC 患者被随机分配接受每日 5 次 20 Gy 的治疗作为胸腔内疾病的姑息治疗，或接受相同的放疗同时连续输注 1 g m(-2) day(-1) 氟尿嘧啶 5 天。根据治疗目的比较两组的生存率、缓解率和症状缓解率，并根据接受的治疗比较毒性。随机接受联合治疗的患者的总体缓解率 (29%) 高于随机接受单独放疗的患者 (16%) (P = 0.035)。然而，治疗组之间在总体生存期、无进展生存期或症状缓解方面没有显着差异。接受RT加氟尿嘧啶治疗的患者的急性毒性明显更多，包括恶心和呕吐（P = 0.01）、食管炎（P = 0.0003）、口腔炎（P = 0.0005）和皮肤反应（P = 0.003）。这项研究首次表明非小细胞肺癌中放疗和输注氟尿嘧啶之间存在相互作用。尽管放疗加氟尿嘧啶的缓解率明显高于单独放疗，但这并没有转化为更有效的姑息治疗。由于该组合产生的毒性明显高于单独放疗，因此不推荐用于 NSCLC 的姑息治疗。然而，这些结果表明，在非小细胞肺癌高剂量根治性放疗中，可能存在利用观察到的抗肿瘤效果增强的机会。
This study assesses the effect of adding continuous-infusion fluorouracil to palliative thoracic radiation therapy (RT) on the rate and duration of symptom relief in patients with advanced non-small-cell lung cancer (NSCLC). Two hundred eligible patients with NSCLC were randomized to receive either 20 Gy in five daily fractions as palliation for intrathoracic disease or the same RT with concurrent continuous infusion of 1 g m(-2) day(-1) fluorouracil for 5 days. Survival, response and rates of symptom relief in the two groups were compared according to treatment intent, and toxicities were compared according to treatment received. The overall response rate was higher in patients randomized to the combination (29%) than in patients randomized to RT alone (16%) (P = 0.035). However, there were no significant differences between the treatment arms in terms of overall or progression-free survival or in palliation of symptoms. Patients treated with RT plus fluorouracil had significantly more acute toxicity, including nausea and vomiting (P = 0.01), oesophagitis (P = 0.0003), stomatitis (P = 0.0005) and skin reaction (P = 0.003). This study suggests for the first time an interaction between RT and infusional fluorouracil in NSCLC. Although RT plus fluorouracil resulted in a significantly higher response rate than achieved with RT alone, this did not translate into more effective palliation. Because the combination produced significantly more toxicity than RT alone, it is not recommended for the palliative treatment of NSCLC. Nevertheless, these results suggest that opportunities may exist for exploitation of the observed enhancement of antitumour effect in the setting of high-dose radical RT for NSCLC.
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影响因子：
158.5
作者：
OCONNELL, M;MARTENSON, JA;RICH, TA
通讯作者：
RICH, TA
DOI：
10.1016/0360-3016(91)90265-6
发表时间：
1991-10-01
影响因子：
7
作者：
CUMMINGS, BJ;KEANE, TJ;CATTON, CN
通讯作者：
CATTON, CN
影响因子：
19.7
作者：
SLAWSON, RG;SCOTT, RM
通讯作者：
SCOTT, RM
影响因子：
158.5
作者：
HERSKOVIC, A;MARTZ, K;EMAMI, B
通讯作者：
EMAMI, B
DOI：
10.1016/0360-3016(85)90307-4
发表时间：
1985-01-01
影响因子：
7
作者：
SIMPSON, JR;FRANCIS, ME;RAO, DV
通讯作者：
RAO, DV