Adoptive immunotherapy for cancer or viruses.
Adoptive immunotherapy for cancer or viruses.
复制标题
对癌症或病毒的收养免疫疗法。
DOI：
10.1146/annurev-immunol-032713-120136
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发表时间：
2014
影响因子：
29.7
通讯作者：
June CH
中科院分区：
文献类型：
--
作者：
Maus MV;Fraietta JA;Levine BL;Kalos M;Zhao Y;June CH
免疫疗法或淋巴细胞输注是治疗癌症和某些慢性病毒感染的有希望的方法。应用合成生物学原理来增强T细胞功能已经导致临床疗效的大幅增加。该领域的主要挑战是识别肿瘤特异性靶点，以避免组织外、靶向毒性。鉴于最近在许多试点试验中取得的疗效进展，临床开发的下一步将需要多中心试验，以便将过继免疫疗法确立为主流技术。
Adoptive immunotherapy, or the infusion of lymphocytes, is a promising approach for the treatment of cancer and certain chronic viral infections. The application of the principles of synthetic biology to enhance T cell function has resulted in substantial increases in clinical efficacy. The primary challenge to the field is to identify tumor-specific targets to avoid off-tissue, on-target toxicity. Given recent advances in efficacy in numerous pilot trials, the next steps in clinical development will require multicenter trials in order to establish adoptive immunotherapy as a mainstream technology.