Discovering the targets of drugs via computational systems biology.
Discovering the targets of drugs via computational systems biology.
复制标题
DOI：
10.1074/jbc.r110.174797
复制
发表时间：
2011-07-08
期刊：
影响因子：
--
通讯作者：
Roth FP
中科院分区：
文献类型：
--
作者：
Chua HN;Roth FP
计算系统生物学正在增强药物作用研究的能力。关于化合物生物效应的研究在规模和可访问性方面有所增加，从而可以与其他大规模实验数据类型相结合。在这里，我们回顾了计算方法，用于阐明药物的预期和不良影响的机制，集体的潜力，改变药物发现和药理学治疗的性质。
Computational systems biology is empowering the study of drug action. Studies on biological effects of chemical compounds have increased in scale and accessibility, allowing integration with other large-scale experimental data types. Here, we review computational approaches for elucidating the mechanisms of both intended and undesirable effects of drugs, with the collective potential to change the nature of drug discovery and pharmacological therapy.