Time-dependent loss of adenosine 5'-monophosphate deaminase activity may explain elevated adenosine 5'-triphosphate levels in senescent erythrocytes
Time-dependent loss of adenosine 5'-monophosphate deaminase activity may explain elevated adenosine 5'-triphosphate levels in senescent erythrocytes
复制标题
5-单磷酸腺苷脱氨酶活性的时间依赖性丧失可能解释衰老红细胞中 5-三磷酸腺苷水平升高
DOI：
10.1182/blood.v74.6.2157.bloodjournal7462157
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发表时间：
1989
期刊：
影响因子：
20.3
通讯作者：
S. Norenberg
中科院分区：
文献类型：
--
作者：
G. Dale;S. Norenberg
来自兔子的衰老红细胞先前显示具有升高的腺嘌呤核苷酸水平。本研究证明，老年红细胞具有正常的腺嘌呤核苷酸合成能力，如正常水平的腺苷激酶所示。然而，衰老的红细胞确实具有降低的腺苷5′-单磷酸脱氨酶水平，腺苷5 ′-单磷酸脱氨酶是参与腺嘌呤核苷酸降解的关键酶。这些在分解代谢能力降低的情况下正常合成能力的情况，以前在人类腺苷5′-单磷酸脱氨酶遗传缺陷中观察到过;这些患者的红细胞积累腺苷5′-三磷酸，就像兔子衰老的红细胞一样。
Senescent erythrocytes from rabbits were previously shown to have elevated levels of adenine nucleotides. The present study documents that aged red blood cells have a normal synthetic capacity for adenine nucleotides, as indicated by normal levels of adenosine kinase. However, senescent erythrocytes do have decreased levels of adenosine 5′-monophosphate deaminase, the critical enzyme involved in degrading adenine nucleotides. These circumstances of a normal synthetic capacity in the presence of decreased catabolic ability were observed previously in a human genetic deficiency of adenosine 5′-monophosphate deaminase; the red blood cells in these patients accumulate adenosine 5′- triphosphate as do senescent erythrocytes in rabbits.