Serum adiponectin in women with polycystic ovarian syndrome and its relation to clinical, metabolic and endocrine parameters
Serum adiponectin in women with polycystic ovarian syndrome and its relation to clinical, metabolic and endocrine parameters
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多囊卵巢综合征女性血清脂联素及其与临床、代谢和内分泌参数的关系
DOI：
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发表时间：
2004
影响因子：
5.4
通讯作者：
J. Głogowska
中科院分区：
文献类型：
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作者：
L. Siemińska;B. Marek;B. Kos;D. Niedziołka;D. Kajdaniuk;M. Nowak;J. Głogowska
多项研究表明，肥胖、胰岛素抵抗、高血压和高脂血症中存在低水平的血清脂联素。我们研究的目的是确定多囊卵巢综合征（PCOS）患者和对照受试者之间的血清脂联素水平是否存在差异。我们还研究了各种心血管危险因素、血清脂联素水平和其他激素（如雄烯二酮、睾酮、雌二醇、DHEAS、性激素结合球蛋白 (SHBG) 和瘦素）之间的关系。我们还分析了血清脂联素与游离雄激素指数之间的相关性。 91 名临床诊断为 PCOS 的女性和 53 名健康对照受试者参加了这项研究，这些受试者按照体重指数 (BMI) 和年龄进行了仔细匹配。获得空腹血样，所有参与者均接受口服 75 g 葡萄糖耐量测试。 PCOS 组中糖耐量受损 (IGT)、高血压和高甘油三酯血症的患病率较高。 PCOS 女性的雄激素浓度升高，游离雄激素指数升高，血清性激素结合球蛋白 (SHBG) 水平降低。尽管与 BMI 相匹配，但观察到病例中的血清脂联素浓度低于对照组（中位值 13.7 μg/ml vs 17.8 μg/ml，p<0.001）。在 PCOS 组中，脂联素水平与以下因素显着相关：BMI（r=-0.32，p=0.002）、腰围（r=-0.32，p=0.003）、腰臀比（WHR，r=-0.38，p=0.001）、甘油三酯（r=-0.31，p=0.007）、性激素结合球蛋白（r=0.30， p=0.003）和游离雄激素指数（r=−0.29，p=0.02）。相反，脂联素水平似乎与总睾酮、DHEAS 和瘦素水平无关。研究发现，与糖耐量正常的 PCOS 女性相比，患有 IGT 的 PCOS 女性的脂联素和性激素结合球蛋白 (SHBG) 水平降低，但经过 BMI 或 WHR 调整后，差异不再具有统计学意义。为了排除由于 PCOS 组中 IGT 患病率较高而可能产生的混杂效应，在排除 IGT 患者后，对 58 名 PCOS 女性和 48 名对照女性组成的亚组重复了这一比较。这些亚组之间的脂联素和性激素结合球蛋白均无显着差异。多元回归分析显示，当考虑所有患者时，血清脂联素浓度最好通过腰臀比、游离雄激素指数和 IGT 的存在来预测。在 PCOS 受试者中，脂联素浓度的唯一独立预测因子是葡萄糖耐量状态。结论：PCOS 组的脂联素水平低于对照组女性，这些差异可能是由于这些病例中 IGT 的患病率较高。
Several studies have demonstrated that low levels of serum adiponectin are present in obesity, insulin resistance, hypertension and hyperlipidemias. The aim of our study was to determine whether serum adiponectin level is different between patients with polycystic ovarian syndrome (PCOS) and control subjects. We also investigated relationships between various cardiovascular risk factors, levels of serum adiponectin and other hormones, such as androstendione, testosterone, estradiol, DHEAS, sex hormone binding globulin (SHBG), and leptin. We also analysed the correlation between serum adiponectin and free androgen index. Ninety-one women with clinical diagnosed PCOS and 53 healthy control subjects, carefully matched by body mass index (BMI) and age, were enrolled in the study. The fasting blood samples were obtained and all participants underwent an oral 75 g glucose tolerance test. The prevalences of impaired glucose tolerance (IGT), hypertension and hypertriglyceridemia were higher in the PCOS group. PCOS women had increased androgen concentrations and higher free androgen index and decreased level of serum SHBG. Lower serum adiponectin concentrations were observed among cases than in controls (median 13.7 μg/ml vs 17.8 μg/ml, p<0.001) despite being matched by BMI. In the PCOS group adiponectin levels correlated significantly with: BMI (r=−0.32, p=0.002), waist circumference (r=−0.32, p=0.003), waist-to-hip ratio (WHR, r=−0.38, p=0.001), triglycerides (r=−0.31, p=0.007), SHBG (r=0.30, p=0.003) and free androgen index (r=−0.29, p=0.02). In contrast, the adiponectin level does not appear to be related to total testosterone, DHEAS and leptin levels. The adiponectin and SHBG levels were found to be decreased in PCOS women with IGT compared to PCOS women with normal glucose tolerance, but after adjustment by BMI or WHR, the differences were no longer statistically significant. To exclude a possible confounding effect due to a higher prevalence of IGT in the PCOS group, this comparison was repeated for the subgroup of 58 PCOS women and 48 control women after excluding those with IGT. Neither adiponectin nor SHBG were significantly different between those subgroups. Multiple regression analysis revealed that serum adiponectin concentrations were best predicted by WHR, free androgen index and presence of IGT when all patients were considered. In PCOS subjects, the only independent predictor of adiponectin concentrations was glucose tolerance status. Conclusions: Lower adiponectin levels were observed in PCOS group than in control women, and these differences were probably due to higher prevalence of IGT in these cases.
影响因子：
5.8
作者：
NESTLER, JE;POWERS, LP;BLACKARD, WG
通讯作者：
BLACKARD, WG
影响因子：
7.7
作者：
Yu, JG;Javorschi, S;Olefsky, JM
通讯作者：
Olefsky, JM
影响因子：
15.9
作者：
Combs, TP;Berg, AH;Rossetti, L
通讯作者：
Rossetti, L