A light-controllable specific drug delivery nanoplatform for targeted bimodal imaging-guided photothermal/chemo synergistic cancer therapy
A light-controllable specific drug delivery nanoplatform for targeted bimodal imaging-guided photothermal/chemo synergistic cancer therapy
复制标题
用于靶向双模成像引导光热/化疗协同癌症治疗的光控特异性药物递送纳米平台
DOI：
10.1016/j.actbio.2018.09.024
复制
发表时间：
2018-10-15
影响因子：
9.7
通讯作者：
Wang, Zhao-Xia
中科院分区：
文献类型：
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作者：
Guo, Yuan;Wang, Xing-Yue;Wang, Zhao-Xia
乳腺癌是一种严重威胁妇女健康和生命的疾病，因为早期诊断困难，治疗效果不理想。因此，迫切需要开发治疗诊断策略，以高准确性和有效性对抗乳腺癌。在这项研究中，我们描述了一种近红外（NIR）光可控，靶向和生物相容性药物递送纳米平台（PFH-PTX@PLGA/SPIO-Her），用于乳腺癌的光声（PA）/超声（US）双峰成像引导光热（PTT）/化学协同癌症治疗。羧基修饰的聚乙二醇化聚乳酸-羟基乙酸共聚物（PLGA-PEG-COOH）构成了纳米平台的骨架。特别地，将抗体Herceptin修饰到纳米平台的表面上用于主动靶向HER 2，以促进纳米平台的肿瘤积聚。超顺磁性氧化铁（SPIO）纳米粒子可作为一种优良的PA显像剂，用于指导肿瘤治疗。当暴露于近红外光时，SPIO还可以将近红外光转化为热能用于光热消融肿瘤。近红外诱导的热效应随后触发全氟己烷（PFH）的光学液滴蒸发（ODV）以产生PFH气泡，这不仅实现了US成像增强，而且有助于从纳米平台释放负载的紫杉醇（PTX），从而显著提高PIT治疗效果。我们的研究结果表明，靶向肿瘤积聚，准确的实时双峰成像，以及在肿瘤部位的大量药物释放都与PTT治疗效果密切相关。因此，治疗诊断纳米平台是一个非常有前途的战略，有针对性的成像引导光热/化学协同肿瘤治疗的高疗效和最小化的副作用。(C)2018 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Breast cancer is a severe threat to the health and lives of women due to its difficult early diagnosis and the unsatisfactory therapeutic efficacy of breast cancer treatments. The development of theranostic strategies to combat breast cancer with high accuracy and effectiveness is therefore urgently needed. In this study, we describe a near-infrared (NIR) light-controllable, targeted and biocompatible drug delivery nanoplatform (PFH-PTX@PLGA/SPIO-Her) for photoacoustic (PA)/ultrasound (US) bimodal imaging-guided photothermal (PTT)/chemo synergistic cancer therapy of breast cancer. Carboxyl-modified PEGylated poly (lactic-co-glycolic acid) (PLGA-PEG-COOH) constituted the skeleton of the nanoplatform. Especially, the antibody Herceptin was modified onto the surface of nanoplatform for active HER2-targing to facilitate the tumor accumulation of the nanoplatform. The encapsulated superparamagnetic iron oxide (SPIO) nanoparticles could be employed as an excellent PA imaging agent to guide tumor therapy. When exposed to NIR light, the SPIO also could transform NIR light into thermal energy for photothermal ablation of tumor. The NIR-induced thermal effect subsequently triggered the optical droplet vaporization (ODV) of perfluorohexane (PFH) to generate PFH gas bubbles, which not only achieved the US imaging enhancement, but also contributed to the release of loaded paclitaxel (PTX) from the nanoplatform for significantly improving PIT therapeutic efficacy. Our results demonstrated that the targeted tumor accumulation, accurate real-time bimodal imaging, and the abundant drug release at the tumor site were all closely associated with the PTT therapeutic efficacy. Therefore, the theranostic nanoplatform is a very promising strategy for targeted imaging-guided photothermal/chemo synergistic tumor therapy with high therapeutic efficacy and minimized side effects. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.