Prognostic effects of glycometabolism changes in lung adenocarcinoma: a prospective observational study
Prognostic effects of glycometabolism changes in lung adenocarcinoma: a prospective observational study
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肺腺癌糖代谢变化的预后影响：一项前瞻性观察研究
DOI：
10.21037/tlcr.2019.10.18
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发表时间：
2019-12-01
影响因子：
4
通讯作者：
Wang, Qun
中科院分区：
文献类型：
--
作者：
Huang, Yiwei;Yang, Xiaodong;Wang, Qun
背景：癌细胞糖代谢的变化为癌细胞提供了生长优势，这在肺腺癌患者的预后预测中也具有重要价值。然而，现有的研究存在争议。
方法：我们连续收集了100对肺腺癌患者的手术标本。通过液相色谱 - 质谱法检测组织中糖代谢中间产物的含量。对本研究纳入的患者每6个月进行一次随访。
结果：包括葡萄糖在内的6种中间产物的含量存在显著差异（P
Background: Changes in glycometabolism of cancer cells provides cancer cells with growth advantages, which are also of great value in the prognosis prediction of the patients with lung adenocarcinoma. However, currently available studies are controversial.Methods: We successively collected 100 paired surgical specimens from patients with lung adenocarcinoma. The content of glycometabolic intermediates in tissues was tested by liquid chromatography-mass spectrometry. Follow-up was conducted every 6 months for patients enrolled in this study.Results: There were significant differences in the contents of six intermediates, including glucose (P