Retinal blood flow regulation and the clinical response to panretinal photocoagulation in proliferative diabetic retinopathy.
Retinal blood flow regulation and the clinical response to panretinal photocoagulation in proliferative diabetic retinopathy.
复制标题
增殖性糖尿病视网膜病变的视网膜血流调节和全视网膜光凝的临床反应。
DOI：
10.1016/s0161-6420(89)32697-2
复制
发表时间：
1989
期刊：
影响因子：
13.7
通讯作者：
Riva,CE
中科院分区：
文献类型：
--
作者：
Grunwald,JE;Brucker,AJ;Petrig,BL;Riva,CE
采用双向激光多普勒测速和单色眼底照相技术研究 23 例糖尿病增生性视网膜病变患者 25 只眼全视网膜光凝术 (PRP) 前后的视网膜血流动力学。 PRP 后，视网膜体积血流量显着降低，视网膜血管对高氧（R）的调节反应增加。研究发现新血管形成消退的存在或不存在与 PRP 后 R 的增加或减少之间存在显着关联。显示新血管形成消退的眼睛比未显示消退的眼睛具有显着更大的平均 Rafer PRP。 PRP 后 R 缺乏改善可能与 PRP 后眼睛继续表现出增殖的剩余缺血或缺氧有关。
Bidirectional laser Doppler velocimetry and monochromatic fundus photography were used to investigate retinal hemodynamics before and after panretinal photocoagulation (PRP) in 25 eyes of 23 diabetic patients with proliferative retinopathy. After PRP, there was a significant decrease in retinal volumetric blood flow rate and an increase in the retinal vascular regulatory response to hyperoxia (R). A significant association was found between the presence or absence of regression of neovascularization and the increase or decrease in R after PRP. Eyes that showed regression of neovascularization had significantly larger average R afer PRP than eyes that did not show regression. Lack of improvement in R after PRP may be related to the presence of remaining ischemia or hypoxia in eyes that continue to show proliferation after PRP.