Host-to-host variation of ecological interactions in polymicrobial infections.
Host-to-host variation of ecological interactions in polymicrobial infections.
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DOI：
10.1088/1478-3975/12/1/016003
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发表时间：
2014-12-04
期刊：
影响因子：
2
通讯作者：
Das J
中科院分区：
文献类型：
--
作者：
Mukherjee S;Weimer KE;Seok SC;Ray WC;Jayaprakash C;Vieland VJ;Swords WE;Das J
在感染和体内平衡中，通常观察到微生物和多细胞宿主之间相互作用的宿主-宿主变异性。然而，大多数用于分析宿主-微生物关系的机制模型，以及大多数用于解释宿主和微生物共同进化的生态学理论，都是基于宿主种群的平均值。通过假设观察到的变化是随机和独立的，这些模型忽略了主机之间的差异的作用。在这里，我们分析的机制，主机到主机的细菌感染动力学的变化，使用的多微生物中耳炎（OM）在龙猫的实验感染模型，结合人口动态模型和最大熵（MaxEnt）为基础的推理方案。我们发现，细菌物种之间的相互作用的性质严格调节主机到主机的变化，在这些相互作用。令人惊讶的是，看似无关的现象，如单个细菌物种在利用营养物质进行生长方面的效率，以及微生物特异性宿主免疫反应，在宿主群体中可能变得相互依赖。后一项发现表明了一种潜在的机制，可能导致在宿主免疫反应和细菌物种的共同进化过程中选择特定的细菌物种菌株。
Host-to-host variability with respect to interactions between microorganisms and multicellular hosts are commonly observed in infection and in homeostasis. However, the majority of mechanistic models used to analyze host-microorganism relationships, as well as most of the ecological theories proposed to explain coevolution of hosts and microbes, are based on averages across a host population. By assuming that observed variations are random and independent, these models overlook the role of differences between hosts. Here, we analyze mechanisms underlying host-to-host variations of bacterial infection kinetics, using the well characterized experimental infection model of polymicrobial otitis media (OM) in chinchillas, in combination with population dynamic models and a Maximum Entropy (MaxEnt) based inference scheme. We find that the nature of the interactions between bacterial species critically regulates host-to-host variations in these interactions. Surprisingly, seemingly unrelated phenomena, such as the efficiency of individual bacterial species in utilizing nutrients for growth, and the microbe-specific host immune response, can become interdependent in a host population. The latter finding suggests a potential mechanism that could lead to selection of specific strains of bacterial species during the coevolution of the host immune response and the bacterial species.
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影响因子：
6.7
作者：
Lysenko ES;Ratner AJ;Nelson AL;Weiser JN
通讯作者：
Weiser JN
DOI：
10.1126/stke.3442006re6
发表时间：
2006-07-18
期刊：
Science's STKE : signal transduction knowledge environment
影响因子：
--
作者：
Hlavacek, William S;Faeder, James R;Fontana, Walter
通讯作者：
Fontana, Walter
DOI：
10.1073/pnas.1314340111
发表时间：
2014-04-08
影响因子：
11.1
作者：
McElroy, Kerensa E.;Hui, Janice G. K.;Thomas, Torsten
通讯作者：
Thomas, Torsten
DOI：
10.1073/pnas.0711712105
发表时间：
2008-04-22
影响因子：
11.1
作者：
Gefen, Orit;Gabay, Chana;Balaban, Nathalie Q.
通讯作者：
Balaban, Nathalie Q.
影响因子：
9.2
作者：
Lysenko, Elena S.;Lijek, Rebeccah S.;Weiser, Jeffrey N.
通讯作者：
Weiser, Jeffrey N.