Lipid Tales of Viral Replication and Transmission.
Lipid Tales of Viral Replication and Transmission.
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DOI：
10.1016/j.tcb.2016.09.011
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发表时间：
2017-03
影响因子：
19
通讯作者：
Altan-Bonnet N
中科院分区：
文献类型：
--
作者：
Altan-Bonnet N
正链RNA病毒是地球上最大的RNA病毒群，包括许多人类、动物和植物病原体。细胞膜在生命周期的各个方面起着关键作用，从进入和复制到组装和退出。特别是，病毒利用膜作为复制的平台和将病毒传播到其他细胞的载体，或者作为单个病毒的包膜，或者作为运输病毒群的囊泡。研究揭示了不同病毒之间的显著趋同，利用具有特定脂质蓝图的膜进行复制和传播。许多动物/人类病毒利用富含磷脂酰肌醇4-磷酸/胆固醇的膜进行复制，而许多植物和昆虫载体动物病毒利用含有磷脂酰乙醇胺/胆固醇的膜进行复制。在传播方面，磷脂酰丝氨酸富集膜广泛用作RNA和DNA病毒的载体。在这里，我们讨论这些膜在病毒发病机制和治疗发展中的作用。
Positive strand RNA viruses are the largest group of RNA viruses on the planet and include many human, animal and plant pathogens. Cellular membranes are key players in all aspects of their life cycle, from entry and replication to assembly and exit. In particular, membranes are virally harnessed to serve as platforms for replication and as carriers to transmit viruses to other cells either as the envelope of a single virus or as the vesicle transporting a population of viruses. Studies have revealed significant convergence among different viruses to utilize membranes with specific lipid blueprints for replication and transmission. For replication many animal/human viruses utilize membranes enriched phosphatidylinositol 4-phosphate/cholesterol whereas many plant and insect-vectored animal viruses exploit ones with phosphatidylethanolamine/cholesterol. For transmission, phosphatidylserine enriched membranes are widely used as carriers for RNA and DNA viruses. Here we discuss the role of these membranes for viral pathogenesis and therapeutic development.