Superlinear growth reveals the Allee effect in tumors
Superlinear growth reveals the Allee effect in tumors
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DOI：
10.1103/physreve.103.042405
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发表时间：
2021-04-09
影响因子：
2.4
通讯作者：
Gatenby, Robert A.
中科院分区：
文献类型：
--
作者：
Azimzade, Youness;Saberi, Abbas Ali;Gatenby, Robert A.
将实验数据整合到生态模型中，在理解推动肿瘤进展的生物学机制方面发挥着核心作用，这些知识可用于开发新的治疗策略。虽然目前的研究强调了肿瘤细胞之间竞争的作用，但它们未能解释最近在人类肿瘤中观察到的超线性生长动力学。在这里，我们通过开发一个模型来研究肿瘤生长动力学，该模型将肿瘤内部的进化动力学与肿瘤微环境相互作用相结合。我们的研究结果表明，肿瘤细胞操纵环境和诱导血管生成的能力驱动超线性生长-一个与Allee效应相容的过程。根据这种理解，我们的模型表明，对于具有较高生长速率的高危肿瘤，抑制血管生成可能是适当的治疗干预。
Integrating experimental data into ecological models plays a central role in understanding biological mechanisms that drive tumor progression where such knowledge can be used to develop new therapeutic strategies. While the current studies emphasize the role of competition among tumor cells, they fail to explain recently observed superlinear growth dynamics across human tumors. Here we study tumor growth dynamics by developing a model that incorporates evolutionary dynamics inside tumors with tumor-microenvironment interactions. Our results reveal that tumor cells' ability to manipulate the environment and induce angiogenesis drives superlinear growth-a process compatible with the Allee effect. In light of this understanding, our model suggests that, for high-risk tumors that have a higher growth rate, suppressing angiogenesis can be the appropriate therapeutic intervention.