Evidence-based analysis on the toxicity of disinfection byproducts in vivo and in vitro for disinfection selection
Evidence-based analysis on the toxicity of disinfection byproducts in vivo and in vitro for disinfection selection
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消毒副产物体内外毒性的循证分析用于消毒选择
DOI：
10.1016/j.watres.2019.114976
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发表时间：
2019-11-15
期刊：
影响因子：
12.8
通讯作者：
Diao, Hongyan
中科院分区：
文献类型：
--
作者：
Dong, Feilong;Chen, Jianing;Diao, Hongyan
消毒是饮用水处理过程中预防水传播感染的关键步骤。然而，氯（最常见的消毒剂之一）与天然有机物（NOM）之间的反应经常导致形成有害的消毒副产物（DBPs）。然而，一些dbp的细胞毒性仍然知之甚少。这些知识对于正确选择消毒过程至关重要。我们研究了舒张肽对小鼠急性肝损伤的影响。随着DBPs浓度的增加，肝损伤的加重程度增加，可能是由于肝巨噬细胞的增加。卤乙腈（HANs）和卤酮（hk）对人肝细胞（Hep3B）细胞的毒性比三卤甲烷（THMs）更大。DBPs的细胞毒性受卤素类型（溴化DBPs和氯化DBPs）和每分子卤素原子数的影响。然后，我们利用中试WDS研究了减少dbp形成的最佳条件。结果表明，dbp的形成顺序为：不锈钢(SS) >球墨铸铁(DI) >聚乙烯（PE）管。更高的流量促进了三根管道中dbp的形成。结果表明，在配水系统中采用PE管和低流量可以减少氯消毒过程中DBPs的形成。(C) 2019 Elsevier Ltd.版权所有。
Disinfection is a key step in drinking water treatment process to prevent water-borne infections. However, reactions between chlorine, one of the most common disinfectants, and natural organic matter (NOM) often lead to the formation of hazardous disinfection byproducts (DBPs). However, the cytotoxicity of some DBPs is still poorly understood. Such knowledge is critical for proper selection of disinfection processes. We investigated the effects of DBPs on mouse acute liver injury. The exacerbation of liver damage increased with the DBPs concentrations, likely due to the increased hepatic macrophages. Haloacetonitriles (HANs) and haloketones (HKs) are more toxic to Human Hepatocellular (Hep3B) cells than trihalomethanes (THMs). Cytotoxicity of DBPs were governed by the halogen type (brominated DBPs > chlorinated DBPs) and the numbers of halogen atoms per molecule. Then, we used the pilot-scale WDS to study the best conditions for reducing the formation of DBPs. The result showed that the formation of DBPs followed the order: stainless-steel (SS) > ductile iron (DI) > polyethylene (PE) pipe. Higher flowrate promoted the formation of DBPs in all three pipes. The results suggest that the formation of DBPs in chlorine disinfection can be reduced by using PE pipes and low flow rate in water distribution systems (WDS). (C) 2019 Elsevier Ltd. All rights reserved.