Sympathetic innervation and noradrenaline content of normal human thyroid tissue from fetal, young, and elderly subjects
Sympathetic innervation and noradrenaline content of normal human thyroid tissue from fetal, young, and elderly subjects
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胎儿、年轻和老年受试者正常人甲状腺组织的交感神经支配和去甲肾上腺素含量
DOI：
10.1007/bf03350368
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发表时间：
1978
影响因子：
5.4
通讯作者：
U. Westgren
中科院分区：
文献类型：
--
作者：
A. Melander;J. Ljunggren;K. Norberg;B. Persson;E. Rosengren;F. Sundler;S. Tibblin;U. Westgren
在人和小鼠中，有形态学和功能证据表明，交感神经系统对滤泡间肾上腺素能神经末梢释放的去甲肾上腺素 (NA) 分泌甲状腺激素有直接的刺激影响。最近在小鼠和大鼠中观察到甲状腺交感神经支配与年龄相关的减少。在本研究中，研究了人类甲状腺组织中交感神经支配和 NA 浓度可能与年龄相关的变化。采用荧光组织化学方法研究滤泡间肾上腺素能神经末梢，并采用荧光法测定NA的组织浓度。在从胎儿、年轻人（20-45岁）和患有甲状腺癌或甲状旁腺功能亢进的老年人（>60岁）甲状腺功能正常的人获得的表面正常的甲状腺组织中，滤泡间肾上腺素能神经末梢的数量似乎随着年龄的增长而减少，并且老年人甲状腺组织中NA的浓度显着低于年轻人。这些发现可能具有功能重要性。
In man, as well as in the mouse, there is morphologic and functional evidence for a direct, stimulatory influence of the sympathetic nervous system on the secretion of thyroid hormone by noradrenaline (NA) released from interfollicular adrenergic nerve terminals. In mice and rats, an age-related reduction of the sympathetic innervation of the thyroid has recently been observed. In the present study, possible age-related variations of the sympathetic innervation and the concentration of NA in human thyroid tissue were examined. Interfollicular adrenergic nerve terminals were studied by fluorescence histochemistry, and the tissue concentration of NA was measured by fluorometry. In apparently normal thyroid tissue, obtained from fetuses, young (20–45), and elderly (>60) euthyroid people with thyroid cancer or hyperparathyroidism, the number of interfollicular adrenergic nerve terminals appeared to be reduced with increasing age, and the thyroid tissue concentration of NA was significantly lower in elderly than in young people. These findings may have functional importance.