Motor control in basal ganglia circuits using fMRI and brain atlas approaches
Motor control in basal ganglia circuits using fMRI and brain atlas approaches
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DOI：
10.1093/cercor/bhi089
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发表时间：
2006-02-01
期刊：
影响因子：
3.7
通讯作者：
Ugurbil, K
中科院分区：
文献类型：
--
作者：
Lehéricy, S;Bardinet, E;Ugurbil, K
在这项研究中，我们研究了运动，运动前区和相关的基底神经节领土的过程中的运动参数，如运动的复杂性和频率。12名右撇子志愿者进行了研究，使用EPI BOLD对比（3 T），同时执行音频起搏的手指敲击任务，旨在区分基底神经节领土。任务改变了动作的复杂性（重复的食指敲击，手指运动的简单序列和10个动作的复杂序列）和频率（从0.5到3 Hz）。激活图被配准到来自死后大脑的3-D大脑图谱上。观察到三种主要的激活模式。在后壳核和感觉运动皮层，信号增加与运动频率，但不与运动的复杂性。在运动前区，前壳核和腹后外侧丘脑，信号增加有规律地增加运动频率和复杂性。在吻侧额区、尾状核、丘脑底核和丘脑腹前/腹外侧区，信号主要在复杂任务和高频任务（3 Hz）中增加。这些数据显示了运动，运动前和关联基底神经节电路在运动相关操作的处理中的不同作用，并表明激活可以精确地定位在基底神经节的整个电路中。
In this study, we examined how the motor, premotor and associative basal ganglia territories process movement parameters such as the complexity and the frequency of movement. Twelve right-handed volunteers were studied using EPI BOLD contrast (3 T) while performing audio-paced finger tapping tasks designed to differentiate basal ganglia territories. Tasks varied movement complexity (repetitive index tapping, simple sequence of finger movements and complex sequence of 10 moves) and frequency (from 0.5 to 3 Hz). Activation maps were coregistered onto a 3-D brain atlas derived from post-mortem brains. Three main patterns of activation were observed. In the posterior putamen and the sensorimotor cortex, signal increased with movement frequency but not with movement complexity. In premotor areas, the anterior putamen and the ventral posterolateral thalamus, signal increased regularly with increasing movement frequency and complexity. In rostral frontal areas, the caudate nucleus, the subthalamic nucleus and the ventral anterior/ventrolateral thalamus, signal increased mainly during the complex task and the high frequency task (3 Hz). These data show the different roles of motor, premotor and associative basal ganglia circuits in the processing of motor-related operations and suggest that activation can be precisely located within the entire circuitry of the basal ganglia.