OPERANT-CONDITIONING OF SPINAL STRETCH REFLEXES IN PATIENTS WITH SPINAL-CORD INJURIES
OPERANT-CONDITIONING OF SPINAL STRETCH REFLEXES IN PATIENTS WITH SPINAL-CORD INJURIES
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DOI：
10.1006/exnr.1994.1199
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发表时间：
1994-12-01
影响因子：
5.3
通讯作者：
WOLF, SL
中科院分区：
文献类型：
--
作者：
SEGAL, RL;WOLF, SL
过度活跃的脊髓牵张反射（SSR）经常发生在脊髓损伤（SCI）中。这些改变的SSR可能会损害运动。最近在猴子和人类受试者中的研究表明，SSR的大小可以使用操作性条件反射进行调制。本研究的目的是确定是否过度活跃的肱二头肌SSRs可以操作性地向下调节。17名慢性（损伤后> 1年）脊髓损伤患者参与研究。受试者接受训练，以保持二头肌背景（预拉伸）肌电图（EMG）活动和肘部角度在预定的水平之前，手肘迅速延长的扭矩电机，以引起二头肌SSR。所有受试者在2周内参加了6个基线阶段。然后，受试者被随机分配到控制组或训练组，在接下来的8周内进行24次训练。到研究结束时，训练组的肱二头肌SSR显著降低（t检验，P < 0.001），而对照组的SSR没有显著降低（t检验，P > 0.05）。减少的SSR持续长达4个月后停止训练。这项研究的结果支持了这一假设，即过度活跃的SSR可以在SCI患者中操作性地向下调节。(C)1994年出版社出版。
Hyperactive spinal stretch reflexes (SSRs) often occur with spinal cord injuries (SCI). These altered SSRs may impair movement. Recent studies in monkeys and human subjects have indicated that the magnitude of SSRs can be modulated using operant conditioning. The purpose of this study was to determine whether hyperactive biceps brachii SSRs could be operantly conditioned downward. Seventeen chronic (> 1 year postlesion) spinal cord-injured patients participated. Subjects were trained to keep biceps background (prestretch) electromyographic (EMG) activity and elbow angle at predetermined levels prior to having the elbow rapidly extended by a torque motor to elicit the biceps SSR. All subjects participated in six baseline sessions over a 2 week period. Then, subjects were randomly assigned to either control or training groups for the next 24 sessions over an 8-week period. By the end of the study, training subjects had significantly reduced biceps SSRs (t test, P < 0.001), while control subjects SSRs were not significantly reduced (t test, P > 0.05). The reduced SSRs persisted for up to 4 months following cessation of training. The results of this study support the hypothesis that hyperactive SSRs can be operantly conditioned downward in SCI patients. (C) 1994 Academic Press, Inc.