Perirhinal cortex area 35 controls the functional link between the perirhinal and entorhinal‐hippocampal circuitry.
Perirhinal cortex area 35 controls the functional link between the perirhinal and entorhinal‐hippocampal circuitry.
复制标题
鼻周皮层 35 区控制着鼻周和内嗅海马回路之间的功能联系。
DOI：
10.1002/bies.202000084
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发表时间：
2021
期刊：
影响因子：
4
通讯作者：
Tominaga T
中科院分区：
文献类型：
--
作者：
Kajiwara R;Tominaga T
在一些实验条件下，由于抑制“墙”，鼻周皮层（PC）的神经元兴奋不会传播到内嗅皮层（EC），这可能有助于在内侧颞叶中产生 PC 和 EC 的功能耦合和解耦合。然而，人们对耦合控制过程知之甚少。在此，我们提出PC中区域35的深层在打开耦合之门方面发挥着关键作用，从而允许PC中的活动传播到EC。通过对啮齿动物脑切片进行电压敏感染料成像，我们发现该区域缓慢失活的钾电导对于诱导兴奋超越抑制控制至关重要。不同神经回路之间的这种耦合持续至少 1 小时。我们阐明了这种网络级可塑性行为及其机制的进一步含义。
In several experimental conditions, neuronal excitation at the perirhinal cortex (PC) does not propagate to the entorhinal cortex (EC) due to a “wall” of inhibition, which may help to create functional coupling and un‐coupling of the PC and EC in the medial temporal lobe. However, little is known regarding the coupling control process. Herein, we propose that the deep layer of area 35 in the PC plays a pivotal role in opening the gate for coupling, thus allowing the activity in the PC to propagate to the EC. Using voltage‐sensitive dye imaging for the brain slices of rodents, we show that a slowly inactivating potassium conductance in this area is essential to induce excitation overtaking the inhibitory control. This coupling between the distinct neural circuits persists for at least 1 h. We elucidate further implications of this network‐level plastic behavior and its mechanism.