Localization of the human frontal eye fields and motor hand area with transcranial magnetic stimulation and magnetic resonance imaging.
Localization of the human frontal eye fields and motor hand area with transcranial magnetic stimulation and magnetic resonance imaging.
复制标题
通过颅磁刺激和磁共振成像对人类额眼区域和运动手区域进行定位。
DOI：
10.1016/s0028-3932(98)00097-9
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发表时间：
1999
期刊：
影响因子：
2.6
通讯作者：
Rafal,R
中科院分区：
文献类型：
--
作者：
Ro,T;Cheifet,S;Ingle,H;Shoup,R;Rafal,R
我们使用经颅磁刺激（TMS）和磁共振成像（MRI）相结合的方法定位的神经解剖学相关的控制扫视眼球运动和手指运动。两名参与者进行TMS，同时执行内源性眼跳任务。经颅磁刺激定位运动手区域，并绘制其前面的区域，以确定经颅磁刺激产生对侧扫视延迟的区域的边界。然后，将基准标记放置在运动手区域及其前方2 cm处，获得MRI扫描，该区域是这两名受试者产生扫视延迟的共同皮层区域。研究还表明，手区域的结构解剖学（通过TMS后对侧手的可见收缩进行生理学定义）与最近报道的旋钮样结构相对应[18，19]。这些结果表明，经颅磁刺激可以是一个精确的，非侵入性的工具，神经解剖映射的皮质结构时，结合结构图像的大脑。
We localized the neuroanatomical correlates for control of saccadic eye movements and for finger movements using a combined transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI) approach. Two participants underwent TMS while performing an endogenous saccade task. The motor hand area was localized by TMS and the region anterior to it was mapped to identify the borders of a region where TMS produced delays in generating contralateral saccades. MRI scans were then obtained with fiducial markers placed over the motor hand area and 2 cm anterior to it, the common cortical region that produced saccadic delays in these two subjects. It was also shown that the structural anatomy of the hand area, physiologically defined by visible contractions of the contralateral hand following TMS, corresponded to the knob-like structure recently reported [18, 19]. These results demonstrate that TMS can be a precise, non-invasive tool for neuroanatomical mapping of cortical structures when combined with structural images of the brain.