Nanotechnological solutions for controlling transmission and emergence of antimicrobial-resistant bacteria, future prospects, and challenges: a systematic review
Nanotechnological solutions for controlling transmission and emergence of antimicrobial-resistant bacteria, future prospects, and challenges: a systematic review
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DOI：
10.1007/s11051-020-04817-7
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发表时间：
2020-05
影响因子：
2.5
通讯作者：
Kenneth Ssekatawa;D. Byarugaba;C. Kato;F. Ejobi;R. Tweyongyere;M. Lubwama;J. Kirabira;E. Wampande
中科院分区：
文献类型：
--
作者：
Kenneth Ssekatawa;D. Byarugaba;C. Kato;F. Ejobi;R. Tweyongyere;M. Lubwama;J. Kirabira;E. Wampande
在全球范围内，多药耐药（MDR）细菌的高流行率，主要是耐甲氧西林金黄色葡萄球菌和耐碳青霉烯肠杆菌科，已被报道。由这种细菌引起的感染是昂贵的，并且由于有效的治疗替代品减少而难以治疗。以目前抗生素生产和批准的速度为中心，预计到2050年，每年可能有多达1000万人死于MDR病原体。为此，正在探索替代战略，如使用纳米技术来配制纳米杀菌剂。这篇系统性综述讨论了控制抗生素耐药性传播和出现的纳米技术解决方案的最新方法、未来前景和挑战。对2018年6月至2019年1月的PubMed和BioMed Central数据库进行了全面的文献检索。使用的检索关键词是“使用纳米技术控制抗生素耐药性”，以提取仅以英文发表的文章，包括所有研究论文，无论发表年份如何。PubMed和BioMed Central数据库文献检索生成了166篇文章，其中49篇全文研究文章符合纳入指南。在纳入的文章中，分别有44.9%、30.6%和24.5%报告使用无机、混合和有机纳米颗粒作为杀菌剂或杀菌剂的载体/增强剂。由于对旧药物和新合成药物的抗菌素耐药性日益普遍，纳米技术等替代办法值得高度赞扬。这是支持在体外，离体和在本审查中评估的体内研究，因为他们报告的有机，无机和混合纳米粒子的高抗肿瘤疗效。
Globally, a high prevalence of multi-drug-resistant (MDR) bacteria, mostly methicillin-resistantStaphylococcus aureusand carbapenem-resistantEnterobacteriaceae, has been reported. Infections caused by such bacteria are expensive and hard to treat due to reduced efficient treatment alternatives. Centered on the current rate of antibiotics production and approvals, it is anticipated that by 2050 up to 10 million people could die annually due to MDR pathogens. To this effect, alternative strategies such as the use of nanotechnology to formulate nanobactericidal agents are being explored. This systematic review addresses the recent approaches, future prospects, and challenges of nanotechnological solutions for controlling transmission and emergence of antibiotic resistance. A comprehensive literature search of PubMed and BioMed Central databases from June 2018 to January 2019 was performed. The search keywords used were “use of nanotechnology to control antibiotic resistance” to extract articles published only in English encompassing all research papers regardless of the year of publication. PubMed and BioMed Central databases literature exploration generated 166 articles of which 49 full-text research articles met the inclusion guidelines. Of the included articles, 44.9%, 30.6%, and 24.5% reported the use of inorganic, hybrid, and organic nanoparticles, respectively, as bactericidal agents or carriers/enhancers of bactericidal agents. Owing to the ever-increasing prevalence of antimicrobial resistance to old and newly synthesized drugs, alternative approaches such as nanotechnology are highly commendable. This is supported by in vitro, ex vivo, and in vivo studies assessed in this review as they reported high bactericide efficacies of organic, inorganic, and hybrid nanoparticles.