CAROTID ATHEROSCLEROSIS MEASURED BY B-MODE ULTRASOUND IN POPULATIONS - ASSOCIATIONS WITH CARDIOVASCULAR RISK-FACTORS IN THE ARIC STUDY
CAROTID ATHEROSCLEROSIS MEASURED BY B-MODE ULTRASOUND IN POPULATIONS - ASSOCIATIONS WITH CARDIOVASCULAR RISK-FACTORS IN THE ARIC STUDY
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DOI：
10.1093/oxfordjournals.aje.a116078
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发表时间：
1991-08-01
影响因子：
5
通讯作者：
ALZOLA, C
中科院分区：
文献类型：
--
作者：
HEISS, G;SHARRETT, AR;ALZOLA, C
为了评估B型超声测量的颈动脉粥样硬化是否与心血管危险因素有关，从1988年至1990年美国四个社区的动脉粥样硬化风险（ARIC）研究队列中抽取了386例颈动脉壁增厚的病例和相同数量的无动脉内膜中层增厚的对照。病例组和对照组在性别、种族、年龄组、研究中心和检查日期方面进行了单独匹配。总胆固醇、低密度脂蛋白（LDL）胆固醇、总甘油三酯、血压和吸烟包年的平均值病例组高于对照组。病例组的平均高密度脂蛋白胆固醇低于对照组。病例对照差异均具有统计学意义。多变量校正的比值比表明，临床和公共卫生为导向的危险因素临界点定义的组间颈动脉粥样硬化风险存在相当大的差异。
To assess whether carotid atherosclerosis measured by B-mode ultrasound is related to cardiovascular risk factors, 386 cases with carotid artery wall thickening and an equal number of controls free of arterial intima-media thickening were drawn from the cohort of the Atherosclerosis Risk in Communities (ARIC) Study examined in four communities in the United States between 1988 and 1990. Cases and controls were individually matched on sex, race, age group, study center, and date of examination. The mean values of total cholesterol, low density lipoprotein (LDL) cholesterol, total triglyceride, blood pressure, and pack-years of cigarette smoking were higher in cases than controls. Mean high density lipoprotein (HDL) cholesterol was lower in cases than controls. Case-control differences were all statistically significant. Multivariable-adjusted odds ratios point to differences of considerable magnitude in the risk of carotid atherosclerosis between groups defined by clinical and public health-oriented risk factor cut-points.