Natural seroconversion to high-risk human papillomaviruses (hrHPVs) is not protective against related HPV genotypes
Natural seroconversion to high-risk human papillomaviruses (hrHPVs) is not protective against related HPV genotypes
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DOI：
10.3109/00365540903501608
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发表时间：
2010-05-01
影响因子：
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通讯作者：
Lehtinen, Matti
中科院分区：
文献类型：
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作者：
Palmroth, Johanna;Namujju, Proscovia;Lehtinen, Matti
在532名宫颈HPV感染的女性队列中，研究了随着时间的推移多种人乳头状瘤病毒(HPV)多种类型血清转换的风险。前瞻性随访10年。在基线时至少有一种HPV抗体阳性(6、11(低危)、16、18、31、33和45(高危，hr))的女性中，随着时间的推移，73-98%的血清转换为一种或多种HPV类型。基线hrHPV血清阳性妇女发生hrHPV血清转换的风险是对照组的2.3倍(95%可信区间为1.1-4.7)，但情况并非如此。未发现自然感染HPV16或HPV18对其他类型的HPV A9或A7的交叉保护作用。这些数据表明，来自自然感染的体液HPV抗体可能不能提供对其他HPV基因型的保护(如缺乏血清转换所表明的)。相反，这些未接种疫苗、HPV抗体阳性的妇女随着时间的推移继续容易受到其他HPV基因型的感染。
The risk of seroconversion for multiple human papillomavirus (HPV) types over time was studied in a cohort of 532 women with cervical HPV infection, prospectively followed-up for > 10 y. Of the women who were HPV-antibody positive for at least 1 of the HPV types (6, 11 (low risk, lr), 16, 18, 31, 33, and 45 (high risk, hr)) at baseline, 73-98% seroconverted for 1 or more HPV types over time. Baseline lrHPV-seropositive women had 2.3-fold risk (95% confidence interval (CI) 1.1-4.7) for hrHPV seroconversion, but the opposite was not the case. Cross-protection by the natural HPV16 or HPV18 infection against other types of the HPV species A9 or A7 was not seen. These data suggest that protection against other HPV genotypes (as indicated by the lack of seroconversion) may not be provided by humoral HPV antibodies derived from a natural infection. Instead, these unvaccinated, HPV-antibody-positive women continue to be susceptible to infections by the other HPV genotypes over time.