Lactate provocation of panic attacks. I. Clinical and behavioral findings.
Lactate provocation of panic attacks. I. Clinical and behavioral findings.
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乳酸激发惊恐发作。
DOI：
10.1001/archpsyc.1984.01790190038004
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发表时间：
1984
影响因子：
--
通讯作者：
D. Klein
中科院分区：
文献类型：
--
作者：
M. Liebowitz;A. Fyer;J. Gorman;D. Dillon;I. Appleby;G. Levy;Samuel W. Anderson;M. Levitt;M. Palij;S. Davies;D. Klein
为了评估乳酸盐诱导的和自然发生的惊恐发作的药理学和现象学的可比性，符合DSM-III惊恐障碍或广场恐怖症伴惊恐发作标准的患者在成功的药物治疗前后输注0.5M外消旋乳酸钠。乳酸盐引起的和自然发生的恐慌发作在病理学上是相似的。治疗后，患者对乳酸的反应与正常对照组没有差异，而治疗前的恐慌率要高得多。这些数据表明，乳酸的行为，通过尚未确定的机制，引发同样的恐慌发作自发发生在脆弱的人。
To assess the pharmacologic and phenomenologic comparability of lactate-induced and naturally occurring panic attacks, patients meeting DSM-III criteria for panic disorder or agoraphobia with panic attacks were infused with 0.5M racemic sodium lactate before and after successful drug treatment. Lactate-induced and naturally occurring panic attacks were symptomatically similar. Following treatment, the patients' response to lactate did not differ from that of normal controls, whereas the pretreatment panic rate was much higher. These data suggest that lactate acts, by as yet unidentified mechanisms, to trigger the same panic attacks as occur spontaneously in vulnerable persons.