Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy - The 15-year Johns Hopkins experience
Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy - The 15-year Johns Hopkins experience
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DOI：
10.1016/s0094-0143(05)70163-4
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发表时间：
2001-08-01
影响因子：
2.4
通讯作者：
Walsh, PC
中科院分区：
文献类型：
--
作者：
Han, M;Partin, AW;Walsh, PC
2404例接受解剖根治性直肠癌切除术的患者平均随访6.3年（1 ~ 17年），这些患者的5年、10年和15年无复发生存率分别为84%、74%和66%。随着临床分期、Gleason评分、术前前列腺特异性抗原（PSA）水平和病理分期的进展，术后复发的可能性增加。Gleason 7肿瘤患者的细分导致更好的分层，Gleason（4+3）和Gleason评分8 - 10疾病患者术后复发的精算可能性相似：然而，Gleason（3+4）疾病患者的复发率与Gleason评分6或Gleason（4+3）疾病患者的复发率有统计学差异。解剖根治性耻骨后前列腺切除术对临床局限性前列腺癌患者可获得良好的长期疗效。随着血清PSA检测和直肠指检筛查的广泛使用，早期前列腺癌男性的比例将继续增加。
In a series of 2404 men who underwent anatomic radical prostatectomy with a mean follow-up of 6.3 years (range 1 to 17), the overall actuarial 5-, 10-, and 15-year recurrence-free survival rates for these men were 84%, 74%, and 66%, respectively. The actuarial likelihood of a postoperative recurrence increased with advancing clinical stage, Gleason score, and preoperative prostate-specific antigen (PSA) level, and pathologic stage. Subdivision of men with Gleason 7 tumors resulted in better stratification with similar actuarial likelihood of postoperative recurrence for men with Gleason (4+3) and Gleason score 8 to 10 diseases: however, recurrence rate in men with Gleason (3+4) diseases was statistically different from that of men with Gleason score 6 or Gleason (4+3) diseases. Excellent long-term results can be obtained with anatomic radical retropubic prostatectomy for men with clinically localized prostate cancer. The proportion of men with early stage prostate cancer will continue to increase with wide use of screening using serum PSA testing and digital rectal examination.