Connectivity of sleep- and wake-promoting regions of the human hypothalamus observed during resting wakefulness
Connectivity of sleep- and wake-promoting regions of the human hypothalamus observed during resting wakefulness
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DOI：
10.1093/sleep/zsy108
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发表时间：
2018-09-01
期刊：
影响因子：
5.6
通讯作者：
Fox, Michael D.
中科院分区：
文献类型：
--
作者：
Boes, Aaron D.;Fischer, David;Fox, Michael D.
下丘脑是调节睡眠-觉醒模式的中枢，其回路已在实验动物中被广泛研究。这项工作已经确定了一个唤醒促进区域在后下丘脑，与其他唤醒促进区域的连接，和一个睡眠促进区域在前下丘脑，与抑制投射到后下丘脑。目前还不清楚人类是否存在类似的组织。在这里，我们使用解剖标志，以确定同源的睡眠和觉醒促进区域的人类下丘脑和研究他们的功能关系，在健康清醒的参与者使用静息状态功能连接磁共振成像。首先，我们确定了下丘脑前部和后部之间的负相关（负相关），这两个区域在睡眠-觉醒调节中具有相反的作用。接下来，我们表明，下丘脑连接预测区域睡眠-觉醒变化的模式，以前在人类中观察到的。具体来说，与下丘脑后部正相关和与下丘脑前部负相关的区域对应于睡眠-清醒状态之间脑血流变化最大的区域。综上所述，这些发现提供了初步的证据，涉及下丘脑回路在动物中的研究，在人类的睡眠-觉醒神经影像学结果，与我们的理解人类的睡眠-觉醒调节和功能意义的睡眠关系。
The hypothalamus is a central hub for regulating sleep-wake patterns, the circuitry of which has been investigated extensively in experimental animals. This work has identified a wake-promoting region in the posterior hypothalamus, with connections to other wake-promoting regions, and a sleep-promoting region in the anterior hypothalamus, with inhibitory projections to the posterior hypothalamus. It is unclear whether a similar organization exists in humans. Here, we use anatomical landmarks to identify homologous sleep-and wake-promoting regions of the human hypothalamus and investigate their functional relationships using resting-state functional connectivity magnetic resonance imaging in healthy awake participants. First, we identify a negative correlation (anticorrelation) between the anterior and posterior hypothalamus, two regions with opposing roles in sleep-wake regulation. Next, we show that hypothalamic connectivity predicts a pattern of regional sleep-wake changes previously observed in humans. Specifically, regions that are more positively correlated with the posterior hypothalamus and more negatively correlated with the anterior hypothalamus correspond to regions with the greatest change in cerebral blood flow between sleep-wake states. Taken together, these findings provide preliminary evidence relating a hypothalamic circuit investigated in animals to sleep-wake neuroimaging results in humans, with implications for our understanding of human sleep-wake regulation and the functional significance of anticorrelations.