Anti-Diabetic Effects of Madecassic Acid and Rotundic Acid.
Anti-Diabetic Effects of Madecassic Acid and Rotundic Acid.
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DOI：
10.3390/nu7125512
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发表时间：
2015-12-02
期刊：
影响因子：
5.9
通讯作者：
Yin MC
中科院分区：
文献类型：
--
作者：
Hsu YM;Hung YC;Hu L;Lee YJ;Yin MC
研究了合成乙酸（MEA）和圆戊酸（RA）的抗糖尿病作用。分别给予0.05%或0.1%浓度的MEA或RA给药6周。摄入MEA（而非RA）会剂量依赖性地降低血浆葡萄糖水平并增加血浆胰岛素水平。MEA，而非RA，摄入剂量依赖性降低纤溶酶原激活物抑制剂-1活性和纤维蛋白原水平；以及恢复糖尿病小鼠血浆中抗凝血素- iii和蛋白C的活性。摄入MEA或RA可降低血浆和肝脏中的甘油三酯和胆固醇水平。通过ORO染色，组织学数据表明，摄入MEA或RA降低了肝脏脂滴。MEA摄入量呈剂量依赖性地降低了糖尿病小鼠心脏和肾脏中活性氧（ROS）和氧化谷胱甘肽水平，增加了谷胱甘肽含量，维持了谷胱甘肽还原酶和过氧化氢酶的活性。MEA摄入剂量依赖性降低了糖尿病小鼠心脏和肾脏中白细胞介素(IL)-1β、IL-6、肿瘤坏死因子-α和单核细胞趋化蛋白-1的水平。0.1%的RA摄入量降低了心脏和肾脏的这些炎症因子水平。这些数据表明，MEA改善了糖尿病小鼠的血糖控制和止血失衡，降低了脂质积累，减轻了氧化应激和炎症应激。因此，合成乙酸可以被认为是一种抗糖尿病药物。
Anti-diabetic effects of madecassic acid (MEA) and rotundic acid (RA) were examined. MEA or RA at 0.05% or 0.1% was supplied to diabetic mice for six weeks. The intake of MEA, not RA, dose-dependently lowered plasma glucose level and increased plasma insulin level. MEA, not RA, intake dose-dependently reduced plasminogen activator inhibitor-1 activity and fibrinogen level; as well as restored antithrombin-III and protein C activities in plasma of diabetic mice. MEA or RA intake decreased triglyceride and cholesterol levels in plasma and liver. Histological data agreed that MEA or RA intake lowered hepatic lipid droplets, determined by ORO stain. MEA intake dose-dependently declined reactive oxygen species (ROS) and oxidized glutathione levels, increased glutathione content and maintained the activity of glutathione reductase and catalase in the heart and kidneys of diabetic mice. MEA intake dose-dependently reduced interleukin (IL)-1β, IL-6, tumor necrosis factor-α and monocyte chemoattractant protein-1 levels in the heart and kidneys of diabetic mice. RA intake at 0.1% declined cardiac and renal levels of these inflammatory factors. These data indicated that MEA improved glycemic control and hemostatic imbalance, lowered lipid accumulation, and attenuated oxidative and inflammatory stress in diabetic mice. Thus, madecassic acid could be considered as an anti-diabetic agent.