Biology of vascular mural cells.
Biology of vascular mural cells.
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DOI：
10.1242/dev.200271
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发表时间：
2023-08
期刊：
影响因子：
4.6
通讯作者：
Arndt F. Siekmann
中科院分区：
文献类型：
--
作者：
Arndt F. Siekmann
脉管系统由以分层模式排列的不同尺寸的血管组成。两个细胞群协同工作，在胚胎发育过程中建立这种模式，并将其应用于生命后期血流需求的变化：排列在血管内表面的内皮细胞，以及相邻的血管壁细胞，包括平滑肌细胞和周细胞。尽管最近在阐明控制其串扰的信号通路方面取得了进展，但关于壁细胞如何影响内皮细胞生物学并从而有助于调节血管形成和直径仍存在许多争论。在这篇综述中，我讨论了壁细胞功能及其与内皮细胞的相互作用，重点是这些相互作用如何确保最佳的血流模式。随后，我介绍了控制壁细胞发育的信号通路，随后概述了壁细胞个体发育，重点是位于不同类型血管上的壁细胞的区别特征。最终，我探索了涉及壁细胞的治疗策略，以缓解组织缺血并提高各种疾病的血管效率。
The vasculature consists of vessels of different sizes that are arranged in a hierarchical pattern. Two cell populations work in concert to establish this pattern during embryonic development and adopt it to changes in blood flow demand later in life: endothelial cells that line the inner surface of blood vessels, and adjacent vascular mural cells, including smooth muscle cells and pericytes. Despite recent progress in elucidating the signalling pathways controlling their crosstalk, much debate remains with regard to how mural cells influence endothelial cell biology and thereby contribute to the regulation of blood vessel formation and diameters. In this Review, I discuss mural cell functions and their interactions with endothelial cells, focusing on how these interactions ensure optimal blood flow patterns. Subsequently, I introduce the signalling pathways controlling mural cell development followed by an overview of mural cell ontogeny with an emphasis on the distinguishing features of mural cells located on different types of blood vessels. Ultimately, I explore therapeutic strategies involving mural cells to alleviate tissue ischemia and improve vascular efficiency in a variety of diseases.