THE INCIDENCE OF WERNICKE ENCEPHALOPATHY IN AUSTRALIA - A NEUROPATHOLOGICAL STUDY OF 131 CASES
THE INCIDENCE OF WERNICKE ENCEPHALOPATHY IN AUSTRALIA - A NEUROPATHOLOGICAL STUDY OF 131 CASES
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DOI：
10.1136/jnnp.46.7.593
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发表时间：
1983-01-01
影响因子：
11
通讯作者：
HARPER, C
中科院分区：
文献类型：
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作者：
HARPER, C
在西澳大利亚一项长达9年的尸检研究中，韦尼克S脑病的发生率为2.8%。发病率似乎在增加。虽然韦尼克S脑病是一种营养障碍，但大多数病例发生在酗酒人群中。临床诊断为韦尼克‘S脑病的仅占20%。临床和病理诊断病例数的这种巨大差异表明，慢性韦尼克‘S脑病’可能是反复亚临床发作的最终结果，占病例总数的83%。S脑病可以被认为是一种进行性疾病，由于患者对硫胺素替代治疗反应良好，早期诊断很重要。为了尽量减少韦尼克S脑病对西方社会的社会和经济影响，可能不得不考虑通过富含维生素来预防酒精饮料。
In a 9 yr necropsy study in Western Australia, the incidence of Wernicke''s encephalopathy was 2.8%. The incidence appears to be increasing. Although Wernicke''s encephalopathy is a nutritional disorder, the majority of cases occur in the alcoholic population. Only 20% of the 131 cases studied were diagnosed clinically as Wernicke''s encephalopathy. This large discrepancy between numbers of cases diagnosed clinically and pathologically suggests that chronic Wernicke''s encephalopathy, which comprised 83% of the cases, may be the end result of repeated subclinical episodes of Wernicke''s encephalopathy. Wernicke''s encephalopathy could be considered a progressive disorder and as patients respond well to thiamin replacement therapy, early diagnosis is important. Prevention by vitamin enrichment of alcoholic beverages may have to be considered in an attempt to minimize the social and economic impact of Wernicke''s encephalopathy on Western society.