TYPE 2 NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION IMAGED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
TYPE 2 NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION IMAGED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
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DOI：
10.1097/iae.0000000000000773
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发表时间：
2015-11-01
影响因子：
3.3
通讯作者：
Souied, Eric H.
中科院分区：
文献类型：
--
作者：
El Ameen, Ala;Cohen, Salomon Y.;Souied, Eric H.
目的：光学相干断层扫描血管造影术是一种新的和非侵入性的技术成像视网膜微血管通过检测反射率的变化，是有关血流。本研究的目的是描述2型新生血管的特点，在年龄相关性黄斑变性使用光学相干断层扫描angiography.Methods：14例2型新生血管的14只眼睛被前瞻性纳入。所有患者均接受了完整的眼科检查，包括彩色和红外眼底照相、荧光素和吲哚菁绿色血管造影、光谱域光学相干断层扫描血管造影和光学相干断层扫描血管造影。在所有病例中，光学相干断层扫描血管造影可检测到2型病变，表现为外层视网膜的高血流病变，肾小球状（4/14）或水母状（10/14），周围有暗晕。视网膜浅层及深层未见异常血流。令人惊讶的是，在假定的脉络膜毛细血管层中也可以观察到2型病变。10/14只眼中，这些肾小球或水母状病变与较厚的主分支相连，该主分支似乎一直延伸到脉络膜层深处。结论：光学相干断层扫描血管造影可能是临床常规诊断2型新生血管的一种新的成像方法。然而，特征的特异性需要在进一步的研究中进行调查。
Purpose: Optical coherence tomography angiography is a novel and noninvasive technique for imaging retinal microvasculature by detecting changes in reflectivity that is related to blood flow. The purpose of this study was to describe Type 2 neovascularization characteristics in age-related macular degeneration using optical coherence tomography angiography.Methods: Fourteen eyes of 14 consecutive patients with Type 2 neovascularization were prospectively included. All patients underwent a complete ophthalmological examination, including color and infrared fundus photography, fluorescein and indocyanine green angiography, spectral domain optical coherence tomography angiography, and optical coherence tomography angiography.Results: In all cases, Type 2 lesions could be detected by optical coherence tomography angiography, presenting as a hyperflow lesion in the outer retina, with a glomerulus (4/14) or medusa shape (10/14), surrounded by a dark halo. The superficial layer and the deep retina showed no abnormal flow. Surprisingly, the Type 2 lesions could also be observed in the presumed choriocapillaris layer. These glomerulus- or medusa-shaped lesions were connected, in 10/14 eyes, to a thicker main branch, which seemed to continue deep into the choroidal layers.Conclusion: Optical coherence tomography angiography may be a new imaging method for the diagnosis of Type 2 neovascularization in clinical routine. However, the specificity of the features needs to be investigated in further studies.