Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms.
Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms.
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DOI：
10.1186/1471-244x-6-56
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发表时间：
2006-12-13
期刊：
影响因子：
4.4
通讯作者：
Tregellas, Jason R
中科院分区：
文献类型：
--
作者：
Rojas, Donald C;Peterson, Eric;Winterrowd, Erin;Reite, Martin L;Rogers, Sally J;Tregellas, Jason R
虽然自闭症患者大脑解剖结构的差异很难用人工追踪方法复制，但自动化全脑分析已经开始发现与自闭症患者经常受损的社会认知过程相关的大脑区域存在一致的差异。我们试图复制这些全脑研究，并将区域体积变化与几种自闭症症状测量相关联。我们对24名诊断为DSM-IV自闭症的个体进行了MRI扫描，并将其与23名年龄匹配的健康对照受试者的扫描结果进行了比较。所有参与者均为男性。使用基于体素的形态测量法（VBM）对全脑区域灰质体积进行体素分析。控制年龄和总灰质体积，额内侧回，左侧中央前回，右侧中央后回，右侧梭状回，尾状核和左侧海马体的体积在自闭症组相对于对照组较大。自闭症组中体积较小的区域仅在小脑中观察到。尾状核，多个额叶和颞叶区域，小脑和重复行为的测量，控制总灰质体积的体积之间的显着偏相关性。孤独症患者的社交和沟通缺陷也与尾状核、小脑和楔前叶体积以及额叶和颞叶区域体积相关。在功能上被确定为在社会认知过程中重要的区域，如内侧额回，感觉运动皮层和颞中回，观察到灰质扩大。此外，我们已经表明，VBM是敏感的社会和重复行为和自闭症区域脑容量之间的关联。
Although differences in brain anatomy in autism have been difficult to replicate using manual tracing methods, automated whole brain analyses have begun to find consistent differences in regions of the brain associated with the social cognitive processes that are often impaired in autism. We attempted to replicate these whole brain studies and to correlate regional volume changes with several autism symptom measures. We performed MRI scans on 24 individuals diagnosed with DSM-IV autistic disorder and compared those to scans from 23 healthy comparison subjects matched on age. All participants were male. Whole brain, voxel-wise analyses of regional gray matter volume were conducted using voxel-based morphometry (VBM). Controlling for age and total gray matter volume, the volumes of the medial frontal gyri, left pre-central gyrus, right post-central gyrus, right fusiform gyrus, caudate nuclei and the left hippocampus were larger in the autism group relative to controls. Regions exhibiting smaller volumes in the autism group were observed exclusively in the cerebellum. Significant partial correlations were found between the volumes of the caudate nuclei, multiple frontal and temporal regions, the cerebellum and a measure of repetitive behaviors, controlling for total gray matter volume. Social and communication deficits in autism were also associated with caudate, cerebellar, and precuneus volumes, as well as with frontal and temporal lobe regional volumes. Gray matter enlargement was observed in areas that have been functionally identified as important in social-cognitive processes, such as the medial frontal gyri, sensorimotor cortex and middle temporal gyrus. Additionally, we have shown that VBM is sensitive to associations between social and repetitive behaviors and regional brain volumes in autism.