Metabolomic analysis of serum by (1) H NMR spectroscopy in amyotrophic lateral sclerosis
Metabolomic analysis of serum by (1) H NMR spectroscopy in amyotrophic lateral sclerosis
复制标题
DOI：
10.1016/j.cca.2010.01.016
复制
发表时间：
2010-04-02
影响因子：
5
通讯作者：
Babu, G. Nagesh
中科院分区：
文献类型：
--
作者：
Kumar, Alok;Bala, Lakshmi;Babu, G. Nagesh
背景：肌萎缩性侧索硬化症（ALS）是一种不可避免的致死性神经系统疾病，其发病机制复杂，对疾病的诊断和监测提出了挑战。方法：采用(1)氢磁共振波谱法对30例ALS患者、10例平山病患者（作为神经系统疾病对照）和25例健康对照的血清代谢物谱进行了研究。结果：与健康对照组相比，肌萎缩侧索硬化症患者谷氨酸含量较高
Background: Amyotrophic lateral sclerosis (ALS), an invariably fatal neurological disorder shows complicated pathogenesis that poses challenges with respect to diagnosis as well as monitoring of disease progression.Methods: We investigated metabolite profiles in the serum of 30 patients with ALS, 10 patients of Hirayama disease, which served as a neurological disease control and 25 healthy controls by using (1) H NMR spectroscopy.Results: Compared to healthy controls, the ALS patients had higher quantities of glutamate (P