DYNAMIC MULTICHANNEL NEAR-INFRARED OPTICAL IMAGING OF HUMAN BRAIN ACTIVITY
DYNAMIC MULTICHANNEL NEAR-INFRARED OPTICAL IMAGING OF HUMAN BRAIN ACTIVITY
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DOI：
10.1152/jappl.1993.75.4.1842
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发表时间：
1993-10-01
影响因子：
3.3
通讯作者：
TAMURA, M
中科院分区：
文献类型：
--
作者：
HOSHI, Y;TAMURA, M
本文展示了利用组织透明的近红外光通过光学成像技术进行功能性大脑绘图。通过最大五通道光学监测系统，除了视觉和听觉刺激之外，我们成功地检测了各种精神任务期间血红蛋白氧合状态和血容量的区域特异性变化。血液供应增加的时间过程因每个大脑区域而异，并且取决于脑力任务期间发生的内部操作的类型。血红蛋白氧合状态的变化也因地区而异。这表明大脑活动激活过程中氧气输送-氧气利用关系存在区域差异。多通道近红外功能成像的实用性已得到充分证明。
The present paper demonstrates functional brain mapping with an optical imaging technique by using tissue-transparent near-infrared light. With a maximal five-channel optical monitoring system, we succeeded in detecting region-specific changes in both the hemoglobin oxygenation state and blood volume during various mental tasks, in addition to visual and auditory stimulation. The time course of increases in blood supply varied with each brain region and depended on the type of internal operations occurring during the mental tasks. Changes in the hemoglobin oxygenation state were also different from region to region. This showed that there were regional variations of the oxygen delivery-oxygen utilization relationship during activation of brain activity. The usefulness of multichannel near-infrared functional imaging was well documented.