Local cerebral glucose utilization in the beagle puppy model of intraventricular hemorrhage.
Local cerebral glucose utilization in the beagle puppy model of intraventricular hemorrhage.
复制标题
脑室内出血小猎犬幼犬模型中的局部脑葡萄糖利用。
作者：
L. Ment;W. Stewart;C. Duncan
用~(14)C-脱氧葡萄糖放射自显影技术对新生Beagle幼犬脑室出血模型的局部脑葡萄糖利用进行了测定。我们的研究表明，在对照幼鼠中，灰质/白质分化摄取14C-2-脱氧葡萄糖，这在成年动物研究中是可以预期的。然而，在脑室出血的幼犬中，所有脑区对14C-2-脱氧葡萄糖的摄取都有明显的均质性，这可能表明在这种神经病理状态下，脑血流和代谢之间的已知耦合丢失。
Local cerebral glucose utilization has been measured by means of carbon-14(14C)-autoradiography with 2-deoxyglucose in the newborn beagle puppy model of intraventricular hemorrhage. Our studies demonstrate gray matter/white matter differentiation of uptake of 14C-2-deoxyglucose in the control pups, as would be expected from adult animal studies. However, there is a marked homogeneity of 14C-2-deoxyglucose uptake in all brain regions in the puppies with intraventricular hemorrhage, possibly indicating a loss of the known coupling between cerebral blood flow and metabolism in this neuropathological condition.