The effects of continuing and discontinuing smoking on the development of chronic kidney disease (CKD) in the healthy middle-aged working population in Japan
The effects of continuing and discontinuing smoking on the development of chronic kidney disease (CKD) in the healthy middle-aged working population in Japan
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DOI：
10.1007/s12199-012-0285-7
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发表时间：
2013-01-01
影响因子：
4.7
通讯作者：
Tabata, Masaji
中科院分区：
文献类型：
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作者：
Noborisaka, Yuka;Ishizaki, Masao;Tabata, Masaji
目的 健康中年工作年龄人群中吸烟与慢性肾病 (CKD) 发展之间的关联强度尚未确定。 方法 这是一项为期 6 年的回顾性观察研究，涉及 4,121 名男性和 2,877 名女性工人，他们均无原发性肾病、糖尿病、严重高血压以及 CKD 的体征和症状。通过试纸法检测蛋白尿，并通过日本肾病学会的方程估算肾小球滤过率 (GFR)。结果 在研究的 6 年中，60 名男性 (1.5 %) 和 21 名女性 (0.7 %) 出现蛋白尿。无论性别如何，与不吸烟者相比，继续吸烟者出现蛋白尿的比值比 (OR) 为 2.52，95% 置信区间 (CI) 为 1.50-4.25，而戒烟者在调整混杂因素后的 OR 为 1.29 (95% CI 0.48-3.42)。在研究人群中，443 名男性 (10.7%) 和 356 名女性 (12.4%) 的 GFR 为
Objectives The strength of the association between smoking and the development of chronic kidney disease (CKD) in the healthy middle-aged working age population has not been established.Methods This was a retrospective 6-year observational study involving 4,121 male and 2,877 female workers who were free of primary kidney disease, diabetes mellitus, severe hypertension, and the signs and symptoms of CKD. Proteinuria was detected by a dipstick method, and glomerular filtration rate (GFR) was estimated by the equation of the Japan Society of Nephrology.Results Sixty men (1.5 %) and 21 women (0.7 %) developed proteinuria over the 6 years of the study. Irrespective of sex, in comparison with non-smokers, those who continued smoking showed an odds ratio (OR) of 2.52 with a 95 % confidence interval (CI) of 1.50-4.25 for developing proteinuria while those who quit smoking showed an OR of 1.29 (95 % CI 0.48-3.42), following adjustment for confounders. Among the study population, 443 men (10.7 %) and 356 women (12.4 %) developed a GFR of