Genetic Dissection of Hematopoiesis Using Drosophila as a Model System
Genetic Dissection of Hematopoiesis Using Drosophila as a Model System
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DOI：
10.1016/s1574-3349(07)18011-x
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Banerjee, Utpal
中科院分区：
文献类型：
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作者：
Evans, Cory J.;Sinenko, Sergey A.;Banerjee, Utpal
对血细胞发育起源的研究表明，控制造血的基因和分子途径在后生动物中是高度保守的。在这一章中，我们总结的进展，了解如何调节果蝇血液发育的分子机制相比，在脊椎动物的类似过程。在果蝇和脊椎动物中，心血管细胞和血细胞的个体发生起源密切相关。在果蝇中，有体内证据表明存在成血管细胞样细胞。此外，调节淋巴腺（果蝇造血器官）发育的分子机制与哺乳动物AGM区的形成之间存在显著的相似性。其他方面也是共同的，包括祖细胞类型的顺序成熟、多能祖细胞或干细胞祖细胞的存在以及维持这些祖细胞需要生态位相互作用。在其发育过程中，果蝇血细胞利用一系列保守的信号通路和转录调节因子来介导细胞命运的指定和分化。果蝇作为一个模型系统的力量是建立良好的，我们对造血的理解，在正常和异常的情况下，肯定会照亮类似的机制，在脊椎动物系统，包括人类。
Investigations into the developmental origins of blood cells have indicated that the genes and molecular pathways controlling hematopoiesis are highly conserved among metazoans. In this chapter we summarize the progress in understanding how the molecular mechanisms regulating Drosophila blood development compare with analogous processes in vertebrates. In both Drosophila and vertebrates, the ontogenetic origins of cardiovascular cells and blood cells are closely related. In Drosophila, there is in vivo evidence for the presence of hemangioblast-like cells. Furthermore, there are significant similarities between the molecular mechanisms regulating the development of the lymph gland, the Drosophila hematopoietic organ, and the formation of the mammalian AGM region. Other aspects are also shared, including the sequential maturation of progenitor cell types, the presence of multipotent or stem cell progenitors, and a requirement for a niche interaction to maintain these progenitors. During their development, Drosophila blood cells utilize an array of conserved signaling pathways and transcriptional regulators to mediate cell fate specification and differentiation. The power of Drosophila as a model system is well established and our understanding of hematopoiesis, in both normal and aberrant contexts, will surely illuminate similar mechanisms in vertebrate systems, including humans.