Clinical and immunological diversity of limbic encephalitis: A model for paraneoplastic neurologic disorders
Clinical and immunological diversity of limbic encephalitis: A model for paraneoplastic neurologic disorders
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DOI：
10.1016/j.hoc.2006.09.011
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发表时间：
2006-12-01
影响因子：
2.4
通讯作者：
Bataller, Luis
中科院分区：
文献类型：
--
作者：
Dalmau, Josep;Bataller, Luis
对理解和管理副肿瘤性神经系统疾病（PND）的最重要贡献是发现许多这些疾病是免疫介导的。据信，细胞毒性T细胞应答和靶向通常由潜在肿瘤表达的神经元蛋白的抗体引起神经系统症状。这些抗体的检测提供了诊断测试，其允许将该病症识别为副肿瘤并将肿瘤直接搜索到选定的器官。本文总结了作者对边缘系统脑炎的发现，并假设类似的方法可用于涉及神经系统其他区域的综合征。
The most important contribution to the understanding and management of paraneoplastic neurologic disorders (PND) is the discovery that many of these disorders are immune mediated. It is believed that cytotoxic T-cell responses and antibodies that target neuronal proteins usually expressed by the underlying tumor cause the neurologic symptoms. The detection of these antibodies has provided diagnostic tests that allow recognition of the disorder as paraneoplastic and direct die search of the tumor to selected organs. This article summarizes die authors' findings of limbic encephalitis and postulates that a similar approach can be used for syndromes involving other areas of the nervous system.