Decreased immunodensities of μ-opioid receptors, receptor kinases GRK 2/6 and β-arrestin-2 in postmortem brains of opiate addicts
Decreased immunodensities of μ-opioid receptors, receptor kinases GRK 2/6 and β-arrestin-2 in postmortem brains of opiate addicts
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DOI：
10.1016/j.molbrainres.2003.11.009
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发表时间：
2004-02-05
期刊：
影响因子：
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通讯作者：
García-Sevilla, JA
中科院分区：
文献类型：
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作者：
Ferrer-Alcón, M;La Harpe, R;García-Sevilla, JA
阿片受体的同源调节，通过G蛋白偶联受体激酶(GRKs)和β-抑制素，是导致阿片耐受和依赖的复杂分子机制的第一步。本研究旨在平行评估阿片类药物过量(海洛因或美沙酮)致死的阿片成瘾者脑内免疫标记的u-阿片受体(糖化蛋白)、两种有代表性的GRK(GRK-2和GRK-6)和β-affstin-2的含量。Mu阿片受体免疫密度降低(66 kDa蛋白：24%，n=24，P
The homologous regulation of opioid receptors, through G protein-coupled receptor kinases (GRKs) and beta-arrestins, is an initial step in the complex molecular mechanisms leading to opiate tolerance and dependence. This study was designed to evaluate in parallel the contents of immunolabeled mu-opioid receptors (glycosylated proteins), two representative GRKs (GRK 2 and GRK 6) and beta-affestin-2 in brains of opiate addicts who had died of an opiate overdose (heroin or methadone). The immunodensities of mu-opioid receptors were decreased (66 kDa protein: 24%, n = 24, P