Nylon Bristles and Elastomers Retain Centigram Levels of Triclosan and Other Chemicals from Toothpastes: Accumulation and Uncontrolled Release
Nylon Bristles and Elastomers Retain Centigram Levels of Triclosan and Other Chemicals from Toothpastes: Accumulation and Uncontrolled Release
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DOI：
10.1021/acs.est.7b02839
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发表时间：
2017-11-07
影响因子：
11.4
通讯作者：
Xing, Baoshan
中科院分区：
文献类型：
--
作者：
Han, Jie;Qiu, Wei;Xing, Baoshan
三氯生（TCS）是一种广谱抗菌剂，用于商业牙膏，据报道对牙齿有益。我们对美国22种流行的手动牙刷进行的研究表明，使用TCS配方牙膏（TCS-TP）刷牙后，常见的牙刷头部件会积累大量的TCS。在使用商业上最畅销的TCS-TP进行3个月的模拟刷牙后，超过三分之一的成年人牙刷显示出2137.5 mg的累积TCS摄取量，相当于每次刷牙使用712.5剂量的TCS。在豌豆大小的儿童牙刷上也观察到了类似的结果。弹性体成分被认为是主要的贡献者，而尼龙刷毛和弹性体都可以作为TCS在刷牙过程中的吸收槽。对含有0.3wt% TCS的六种不同TCS-TP的研究显示出相似的TCS积累概况。在转换为不含TCS的替代品后，吸收的TCS逐渐释放到牙膏浆料中。TCS的释放，通常以分数（
Triclosan (TCS), a broad-spectrum antimicrobial, is used in commercial toothpastes with reported dental benefits. Our studies on 22 popular manual toothbrushes in the U.S. showed that common toothbrush head components can accumulate substantial amounts of TCS after brushing with TCS-formulated toothpastes (TCS-TPs). After simulated 3-month brushing with a commercial best-selling TCS-TP, over one third of the adults toothbrushes showed a cumulative TCS uptake of 2137.5 mg, equivalent to 712.5 doses of the TCS used per brushing. Similar results were observed on childrens toothbrushes with small pea-size heads. Elastomer components were found to be the main contributor while both nylon bristles and elastomers could act as absorptive sinks for TCS during brushing. Studies on six different TCS-TPs containing 0.3 wt% TCS showed similar profiles of TCS accumulation. The absorbed TCS was gradually released into toothpaste slurries after switching to TCS-free alternatives. Release of TCS, which typically measured at a fraction (