Association of rotavirus and human immunodeficiency virus infection in children hospitalized with acute diarrhea, Lusaka, Zambia.
Association of rotavirus and human immunodeficiency virus infection in children hospitalized with acute diarrhea, Lusaka, Zambia.
复制标题
赞比亚卢萨卡因急性腹泻住院儿童的轮状病毒和人类免疫缺陷病毒感染的关联。
DOI：
10.1093/infdis/169.4.897
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
DuPont,HL
中科院分区：
文献类型：
--
作者：
Oshitani,H;Kasolo,FC;Mpabalwani,M;Luo,NP;Matsubayashi,N;Bhat,GH;Suzuki,H;Numazaki,Y;Zumla,A;DuPont,HL
在赞比亚卢萨卡，轮状病毒（RV）和人体免疫缺陷病毒（HIV）感染普遍并存；在537例连续研究的5岁以下腹泻住院婴儿中，132例（25%）两种病毒感染均呈阳性。RV感染的婴儿比RV阴性的婴儿更年轻（P< 0.05），两种病毒同时感染的婴儿更容易出现脱水（P< 0.05）。与RV感染无关，hiv感染儿童在入院时更常出现呼吸道症状（P< 0.0001），体重不足（P< 0.0001）的发生率高于hiv阴性儿童。hiv阳性婴儿死亡率最高（P< 0.05），合并RV感染不增加死亡风险。这项研究表明，虽然RV和HIV感染在非洲的一个地区普遍共存，但RV感染在HIV阳性婴儿中并不常见，病情也不严重。
In Lusaka, Zambia, rotavirus (RV) and human immunodeficiency virus (HIV) infection commonly coexist; 132 (25%) of 537 consecutively studied infants <5 years old hospitalized with diarrhea were positive for both viral infections. Infants with RV infection were younger than those who were RV-negative (P>.05), and infants with both viruses more frequently experienced dehydration (P< .05). HIV-infected children more often exhibited respiratory symptoms on admission to the study (P< .0001) and were more frequently underweight (P< .0001) than were HIV-negative children, independent of RV infection. The mortality rate was highest in HIV-positive infants (P< .05), and coinfection with RV did not increase the risk of fatality. This study demonstrates that while RV and HIV infections commonly coexist in one region of Africa, RV infection is no more common nor is the illness more severe in HIV-positive infants.