Is there a risk of cancer development after Campylobacter infection?
Is there a risk of cancer development after Campylobacter infection?
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DOI：
10.3109/00365521003734133
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发表时间：
2010-08-01
影响因子：
1.9
通讯作者：
Ekbom, Anders
中科院分区：
文献类型：
--
作者：
Brauner, Annelie;Brandt, Lena;Ekbom, Anders
目标。所有的空肠弯曲杆菌种类都会产生一种基因毒素，这种毒素会导致DNA双链断裂，从而增加患癌症的风险，尤其是在胃肠道中。材料和方法。包括1989年至2006年期间斯德哥尔摩县所有空肠梭菌检测呈阳性的个体。该队列随访至2007年12月31日，以了解总体和特定部位的癌症发生情况。通过与背景人群的比较计算标准发病率（SIR）和95%置信区间（CI）。结果。有16276人检测出空肠梭菌阳性，产生124387人年。排除第一年随访后，总体癌症风险与预期SIR = 0.95 （95% CI 0.82-1.09）和随访10年或更长时间后均无差异；Sir = 0.91 （95% ci 0.71-1.16）。胃肠道癌症的风险没有增加，但黑色素瘤的风险显著增加，SIR = 1.84 (95% CI 1.27-2.57)，鳞状细胞皮肤癌的风险显著增加，SIR = 1.52 (95% CI 1.01-2.19)，而男性呼吸道癌症的风险显著降低，SIR = 0.32 （95% CI 0.12-0.70）。结论。我们的结果表明，至少在第一个十年中，空肠梭菌感染后没有额外的恶性肿瘤风险。此外，如果未来的研究结果在其他人群中得到复制，那么呼吸系统癌症风险降低的发现可能会引起人们的兴趣。
Objective. All Campylobacter jejuni species produce a genotoxin, which induce DNA double strand breaks, could lead to an increased risk of cancer especially in the gastro-intestinal tract. Material and methods. All individuals in Stockholm County who tested positive with C. jejuni between 1989 and 2006 were included. The cohort was followed-up until December 31, 2007 for the occurrence of cancer, overall and site specific. Standard incidence ratios (SIR) with 95% confidence intervals (CI) were calculated by comparisons with the background population. Results. There were 16,276 individuals who tested positive for C. jejuni generating 124,387 person years. Excluding the first year of follow-up the overall risk for cancer did neither differ from that expected SIR = 0.95 (95% CI 0.82-1.09) nor after 10 years or more of follow-up; SIR = 0.91 (95% CI 0.71-1.16). There was no increased risk for cancer in the gastro-intestinal tract, but there were significantly increased risks for melanomas SIR = 1.84 (95% CI 1.27-2.57) and squamous cell skin cancer SIR = 1.52 (95% CI 1.01-2.19) while a significantly decreased risk of respiratory cancers among males SIR = 0.32 (95% CI 0.12-0.70) was observed. Conclusions. Our results indicate no excess risks of malignancies following an infection by C. jejuni at least during the first decade. Furthermore, the finding of a decreased risk of respiratory cancers could be of interest, if the results are reproduced in future studies in other populations.