Pcgf5 Contributes to PRC1 (Polycomb Repressive Complex 1) in Developing Cardiac Cells
Pcgf5 Contributes to PRC1 (Polycomb Repressive Complex 1) in Developing Cardiac Cells
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DOI：
10.1007/978-4-431-54628-3_43
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
M. Shirai;Y. Takihara;T. Morisaki
中科院分区：
文献类型：
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作者：
M. Shirai;Y. Takihara;T. Morisaki
Polycomb-group （PcG）蛋白通过特异性组蛋白修饰维持转录沉默，对胚胎和成体干细胞的细胞命运转变和正常发育至关重要。PcG蛋白分子分析的最新进展表明，PRC1的不同亚基组成赋予胚胎和成体干细胞调控的特异性和非重叠功能。在这里，我们概述了最近关于PcG蛋白在心脏发育中的作用的发现，重点是PcG复合物的多样性。
Polycomb-group (PcG) proteins maintain transcriptional silencing through specific histone modification and are essential for cell-fate transition and proper development of embryonic and adult stem cells. Recent advances in molecular analysis of PcG proteins have revealed that the distinct subunit composition of PRC1 confers specific and nonoverlapping functions for regulation of embryonic and adult stem cells. Here, we provide an overview of recent findings regarding the role of PcG proteins in cardiac development, with focus on the diversity of PcG complexes.