Nature and nurture in infant appetite: analysis of the Gemini twin birth cohort
Nature and nurture in infant appetite: analysis of the Gemini twin birth cohort
复制标题
DOI：
10.3945/ajcn.2009.28868
复制
发表时间：
2010-05-01
影响因子：
7.1
通讯作者：
Wardle, Jane
中科院分区：
文献类型：
--
作者：
Llewellyn, Clare H.;van Jaarsveld, Cornelia H. M.;Wardle, Jane
工作背景：在儿童和成年人中，食欲性状受到强烈的遗传影响，但没有研究研究过婴儿早期的食欲，即使食欲旺盛与肥胖的风险较高有关。目的：目的是调查4种食欲性状在婴儿早期的遗传力，这些食欲性状已被证明在儿童后期可遗传。设计：数据来自Gemini研究，这是一项基于人口的双胞胎样本（n = 2402对），2007年出生于英格兰和威尔士。为了描述他们的孩子在出生后的前3个月内的饮食行为，当他们仍然完全用牛奶喂养时，双胞胎的父母完成了婴儿饮食行为问卷的4个分量表：“食物的享受”，“食物反应”，“进食缓慢”和“饱腹感反应”。which is a relatively low genetic model.“（84%; 95% CI：83%，86%）和饱腹感反应性（72%; 95% CI：65%，80%）和中度食物反应性（59%; 95% CI：52%，65%）结论：食欲性状的遗传变异可能是基因影响婴儿期生长速度的途径之一。早期发现婴儿食欲旺盛，可能有助于在体重过度增加之前采取措施减弱这些特征的表达。美国临床营养杂志2010; 91：1172-9。
Background: A strong genetic influence on appetitive traits has been shown in children and adults, but no studies have examined appetite in early infancy, even though avidity of appetite has been linked with a higher risk of obesity.Objective: The objective was to investigate the heritability in early infancy of 4 appetitive traits that have been shown to be heritable later in childhood.Design: Data are from the Gemini Study, a population-based sample of twins (n = 2402 pairs) born in England and Wales in 2007. To describe their children's eating behavior during the first 3 mo of life while they were still exclusively milk fed, the parents of the twins completed 4 subscales of the Baby Eating Behavior Questionnaire: "enjoyment of food," "food responsiveness," "slowness in eating," and "satiety responsiveness. "Heritability was estimated by using quantitative genetic model fitting.Results: Heritability was high for slowness in eating (84%; 95% CI: 83%, 86%) and satiety responsiveness (72%; 95% CI: 65%, 80%) and moderate for food responsiveness (59%; 95% CI: 52%, 65%) and enjoyment of food (53%; 95% CI: 43%, 63%).Conclusions: Genetically determined variability in appetitive traits may be one of the pathways through which genes influence the growth rate in infancy. Early identification of infants with avid appetites may make it possible to implement strategies to attenuate the expression of these traits before excessive weight gain occurs. Am J Clin Nutr 2010; 91: 1172-9.