Breastfeeding and thyroid cancer risk in women: A dose-response meta-analysis of epidemiological studies.
Breastfeeding and thyroid cancer risk in women: A dose-response meta-analysis of epidemiological studies.
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DOI：
10.1016/j.clnu.2015.12.005
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Wu L
中科院分区：
文献类型：
--
作者：
Yi X;Zhu J;Zhu X;Liu GJ;Wu L
流行病学研究表明，母乳喂养与甲状腺癌风险之间的关联并不一致。为了更好地阐明这种关联，包括评估潜在的剂量反应关系，我们进行了全面的荟萃分析。 We searched PubMed (MEDLINE) up to November 2015 for prospective studies or case-control studies that evaluated the association between breastfeeding and risk of thyroid cancer.使用固定效应模型汇总效应估计。 Nine reports (2 prospective studies, 6 case-control studies and 1 pooled analysis of 14 case-control studies) involving 2423 cases and 350081 non-cases were identified. After pooling relevant studies, there was a significant inverse association between ever breastfeeding and risk of thyroid cancer (RR=0.91, 95% CI 0.83–0.99), with minor heterogeneity (I2=10.1%).剂量反应分析显示母乳喂养时间与甲状腺癌风险之间存在显着的线性关系。母乳喂养增加 1 个月与甲状腺癌风险的总体 RR 为 0.983 (95% CI 0.98–0.99)。 When focusing on cohort studies, a more prominent linear dose-response relationship was detected, with the combined RR for every increment of 1 month of breastfeeding to be 0.965 (95% CI 0.96–0.97).这项荟萃分析表明，母乳喂养可能与甲状腺癌风险呈负相关。此外，更长的母乳喂养时间可能会进一步降低患甲状腺癌的风险。如果在大规模前瞻性研究中得到验证，我们的研究结果可能会对影响女性母乳喂养的决定产生影响。
The association between breastfeeding and thyroid cancer risk is not consistent from epidemiological studies. To better clarify the association including assessing a potential dose-response relationship, we conducted a comprehensive meta-analysis. We searched PubMed (MEDLINE) up to November 2015 for prospective studies or case-control studies that evaluated the association between breastfeeding and risk of thyroid cancer. Effect estimates were pooled using a fixed-effects model. Nine reports (2 prospective studies, 6 case-control studies and 1 pooled analysis of 14 case-control studies) involving 2423 cases and 350081 non-cases were identified. After pooling relevant studies, there was a significant inverse association between ever breastfeeding and risk of thyroid cancer (RR=0.91, 95% CI 0.83–0.99), with minor heterogeneity (I2=10.1%). The dose-response analysis revealed a significant linear relationship between the duration of breastfeeding and risk of thyroid cancer. The summary RR for an increment of 1 month of breastfeeding with risk of thyroid cancer was 0.983 (95% CI 0.98–0.99). When focusing on cohort studies, a more prominent linear dose-response relationship was detected, with the combined RR for every increment of 1 month of breastfeeding to be 0.965 (95% CI 0.96–0.97). This meta-analysis suggests that breastfeeding is potentially inversely associated with thyroid cancer risk. Also longer duration of breastfeeding may further decreases thyroid cancer risk. If validated in large-scale prospective studies, our findings may have implications for impacting women’s decision in breastfeeding.