Antitumor activity of 2-amino-4,4α-dihydro-4α, 7-dimethyl-3H-phenoxazine-3-one against Meth A tumor transplanted into BALB/c mice
Antitumor activity of 2-amino-4,4α-dihydro-4α, 7-dimethyl-3H-phenoxazine-3-one against Meth A tumor transplanted into BALB/c mice
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2-氨基-4,4α-二氢-4α,7-二甲基-3H-吩恶嗪-3-酮对BALB/c小鼠移植的Meth A肿瘤的抗肿瘤活性
DOI：
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
A. Tomoda
中科院分区：
文献类型：
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作者：
H. Mori;K. Honda;R. Ishida;T. Nohira;A. Tomoda
我们研究了2-氨基-4，4 α-二氢-4 α，7-二甲基-3H-吩恶嗪-3-酮（Phx）对移植到BALB/c小鼠体内的Meth A癌细胞的抗肿瘤活性和副作用。通过2-氨基-5-甲基苯酚与牛溶血产物反应合成的Phx以1和5 mg/kg的剂量腹膜内给予移植有Meth A肿瘤细胞的BALB/c小鼠。Phx对小鼠Meth A肿瘤有较强的抗肿瘤活性，与5-FU相似。Phx在5 mg/kg剂量下的抗肿瘤活性与5-FU在7.8 mg/kg剂量下的抗肿瘤活性相当。相反，与5-FU不同，Phx没有引起白细胞减少，同时显示出较强的抗肿瘤活性。该化合物也几乎没有引起体重变化，也没有出现小鼠消瘦。这些结果表明，Phx具有很强的抗肿瘤活性，但产生较低的副作用，并表明Phx可用于未来的治疗目的。
We examined the in vivo effect of 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one (Phx) on Meth A carcinoma cells transplanted into BALB/c mice, in terms of both anti-tumor activity and side effects. Phx, which was synthesized by the reaction of 2-amino-5-methylphenol with bovine hemolysates, was administered i.p. at doses of 1 and 5 mg/kg to BALB/c mice transplanted with Meth A tumor cells. Phx exerted a strong antitumor activity to Meth A tumor growing in the mice as 5-fluorouracil (5-FU) did. The antitumor activity of Phx at the dose of 5 mg/kg was comparable to that of 5-FU at the dose of 7.8 mg/kg. In contrast, unlike 5-FU, Phx did not cause leukopenia while showing a strong antitumor activity. The compound also produced little changes in body weight and no wasting of mice developed. These results show that Phx has strong anti-tumor activity, but exerts lower side effects and suggest that Phx is available for therapeutic purposes in the future.
影响因子：
2.9
作者：
F. Takusagawa;L. Wen;W. Chu;Q. Li;K. T. Takusagawa;R. G. Carlson;R. F. Weaver
通讯作者：
F. Takusagawa;L. Wen;W. Chu;Q. Li;K. T. Takusagawa;R. G. Carlson;R. F. Weaver
从合成五肽内酯前体酶法合成放线菌素 D 和含有 N-甲基丙氨酸的类似物。
DOI：
10.7164/antibiotics.43.731
发表时间：
1990
期刊：
The Journal of antibiotics
影响因子：
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作者：
Katz,E;Lloyd,HA;Mauger,AB
通讯作者：
Mauger,AB