EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphine dependence, tolerance and withdrawal in rhesus monkeys
EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphine dependence, tolerance and withdrawal in rhesus monkeys
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DOI：
10.1016/j.brainres.2005.06.037
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发表时间：
2005-08
期刊：
影响因子：
2.9
通讯作者：
Ning Liu;Yancheng Liu;Yaodong Fan;Hualin Yu;F. A. Wilson;Yuanye Ma;Xintian Hu
中科院分区：
文献类型：
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作者：
Ning Liu;Yancheng Liu;Yaodong Fan;Hualin Yu;F. A. Wilson;Yuanye Ma;Xintian Hu
研究成瘾过程中前额皮质（PFC）的活动对于理解药物滥用后 PFC 损伤的神经机制具有重要意义。然而，从灵长类动物获得的数据有限，并且很少有研究分析伽马波段的脑电图（EEG），伽马波段在认知功能中发挥着重要作用。此外，目前尚不清楚药物滥用是否以类似的方式影响眶额皮层（OFC）和背外侧前额皮质（DLPFC）——前额皮质的两个最重要的子区域。本研究的目的就是解决这些问题。我们记录了三只恒河猴的 OFC 和 DLPFC 的脑电图。所有动物均接受一个疗程的盐水（0.9％氯化钠，2毫升）注射（5天），随后注射10天吗啡（每12小时），然后再注射一系列盐水（7天）。本研究的一个主要发现是，在猴子的 OFC 和 DLPFC 中注射吗啡后，短时间内所有频段的脑电图功率均降低。伽玛能量不仅在吗啡注射后短时间内下降，而且持续到注射后12小时。此外，我们发现虽然注射后30-35分钟OFC和DLPFC的EEG活动变化相似，但DLPFC对吗啡的作用比OFC更敏感。
Investigating the activities of the prefrontal cortex (PFC) in the process of addiction is valuable for understanding the neural mechanism underlying the impairments of the PFC after drug abuse. However, limited data are obtained from primate animals and few studies analyze Electroencephalogram (EEG) in the gamma band, which plays an important role in cognitive functions. In addition, it is yet unclear whether drug abuse affects the orbitofrontal cortex (OFC) and dorsolateral PFC (DLPFC) – the two most important subregions of the PFC – in similar ways or not. The aim of this study is to address these issues. We recorded EEG in the OFC and DLPFC in three rhesus monkeys. All animals received a course of saline (NaCl 0.9%, 2 ml) injection (5 days) followed by 10 days of morphine injection (every 12 h), and then a further series of saline injection (7 days). A main finding in the present study was that morphine decreased EEG power in all frequency bands in a short period after injection in both the OFC and DLPFC in monkeys. And gamma power decreased not just in a short period after morphine injection but lasted to 12 h after injection. Moreover, we found that although the changes in EEG activities in the OFC and DLPFC at 30–35 min after injection were similar, the DLPFC was more sensitive to the effect of morphine than the OFC.