Poly(ADP-ribosyl)ation, a molecular switch of transcription, shows an attractive relationship with urokinase expression
Poly(ADP-ribosyl)ation, a molecular switch of transcription, shows an attractive relationship with urokinase expression
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DOI：
10.1160/th04-09-0605
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发表时间：
2005-02-01
影响因子：
6.7
通讯作者：
Del Rosso, M
中科院分区：
文献类型：
--
作者：
Chevanne, M;Caldini, R;Del Rosso, M
聚（ADP-核糖基）化是蛋白质的翻译后修饰，其包括ADP-核糖单元从NAD（+）转移到蛋白质受体上以形成长的和分支的聚合物。PARP活性受到遗传毒性刺激或环境因素的刺激。带负电荷的聚合物改变涉及基因组稳定性、基因表达、细胞增殖和分化的几种蛋白质的功能活性。越来越多的证据支持这样的观点，即PARP在DNA修复和DNA转录中的关键位置，不仅在组织损伤中影响细胞存活，而且在环境稳态改变中也影响细胞存活。因此，它可以被认为是控制转录的分子开关，最终导致细胞的选择和死亡。本文综述了PARP活性的最新研究结果，并特别强调了其在尿激酶型纤溶酶原激活剂上调中的作用。
Poly(ADP-ribosyl)ation is a posttranslational modification of proteins that consists in the transfer of ADP-ribose units from NAD(+) onto protein acceptors to form long and branched polymers. PARP activity is stimulated either by genotoxic stimuli or by environmental factors. The negative charged polymers alter functional activity of several proteins involved in genome stability, gene expression, cell proliferation and differentiation. Increasing evidence supports the view that PARP, for its crucial position in DNA repair and DNA transcription, influences cell survival not only during tissue injure, but also in environmental homeostasis modification. Therefore, it may be considered a molecular switch in the control of transcription, eventually leading to the choice of cell for life and death. This review summarizes the recent findings on PARP activity and special emphasis is given to its role in urokinase-type plasminogen activator upregulation.