NONINVASIVE MEASUREMENT OF INTRARENAL BLOOD-FLOW DISTRIBUTION - KINETIC-MODEL OF RENAL I-123 HIPPURAN HANDLING
NONINVASIVE MEASUREMENT OF INTRARENAL BLOOD-FLOW DISTRIBUTION - KINETIC-MODEL OF RENAL I-123 HIPPURAN HANDLING
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DOI：
10.1152/ajprenal.1995.269.4.f571
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发表时间：
1995-10-01
期刊：
影响因子：
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通讯作者：
DEZEEUW, D
中科院分区：
文献类型：
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作者：
JANSSEN, WMT;BEEKHUIS, H;DEZEEUW, D
提出了一种无创测量肾皮质和髓质内血流分布的新技术。这项技术包括分析I-123标记的河马肾图，根据描述I-123-河马从心脏(输入)通过肾皮质和髓质流向膀胱(输出)的动力学模型。该方法在麻醉犬身上进行了验证，并与标准微球注射技术进行了比较。应用安慰剂(n=6)、血管紧张素I(n=5)或心钠素(n=5)引起肾内血流分布的改变。微球测量的左肾髓质血流量占肾总血流量的12+/-1%，肾造影术测量的左肾髓质血流量占肾总血流量的15+/-1%。在注射安慰剂期间，与基线相比，骨髓血流量略有下降，两种方法测得的降幅分别为2+/-6(微球)和1+/-8%(肾造影术)。血管紧张素I输注导致骨髓血流量显著下降42+/-11(微球)和57+/-8%(肾造影术)。相反，输注心钠素引起两种方法测得的髓质血流量略有增加(分别为9+/-3和12+/-11%)。左肾血流绝对值和百分比变化与微球相关(左肾r=0.67，P=0.005；右肾r=0.62，P=0.003；r=0.68，P=0.004)。我们的结论是，所提出的肾脏I-123-河马处理的动力学模型可以用来测量肾内血流分布的变化，并且由于其无创的特性，可能在临床研究中使用。
A new technique for noninvasive measurement of intrarenal blood flow distribution over cortex and medulla is proposed. The tech nique involves analysis of I-123-labeled hippuran renography, according to a kinetic model that describes the flow of I-123- hippuran from the heart (input) through the renal cortex and medulla to the bladder (output). The method is validated and compared with the standard microsphere injection technique in anesthetized dogs. Changes in intrarenal blood flow distribution were induced by infusion of placebo (n = 6), angiotensin I (n = 5), or atrial natriuretic factor (n = 5). Baseline percentage medullary blood flow in the left kidney was 12 +/- 1% of total renal blood flow measured with microspheres and 15 +/- 1% with renography. During infusion of the placebo, medullary blood flow decreased slightly compared with baseline, as measured with both methods, by 2 +/- 6 (microspheres) and 1 +/- 8% (renography). Infusion of angiotensin I caused a marked fall in medullary blood flow by 42 +/- 11 (microspheres) and 57 +/- 8% (renography). In contrast, infusion of atrial natriuretic factor caused a small rise in medullary blood flow as measured with both methods (9 +/- 3 and 12 +/- 11%, respectively). The absolute and percent changes in medullary blood flow measured with renography correlated with those measured with microspheres (left kidney: r = 0.67, P = 0.005; r = 0.71, P = 0.003, respectively; right kidney: r = 0.62, P = 0.01; r = 0.68,P = 0.004, respectively). We conclude that the proposed kinetic model of renal I-123-hippuran handling can be used to measure changes in intrarenal blood flow distribution and, because of its noninvasive character, may be of use in clinical studies.