Cognitive functioning in preclinical vascular dementia -: A 6-year follow-up
Cognitive functioning in preclinical vascular dementia -: A 6-year follow-up
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DOI：
10.1161/01.str.0000133396.90718.83
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发表时间：
2004-08-01
期刊：
影响因子：
8.3
通讯作者：
Bäckman, L
中科院分区：
文献类型：
--
作者：
Laukka, EJ;Jones, S;Bäckman, L
背景和目的-最近的研究表明，在诊断为血管性痴呆（VaD）之前的几年中存在认知缺陷。本研究的目的是（1）通过检查诊断前6年是否已经存在认知缺陷来扩展先前的研究，以及（2）在控制了以前的血管疾病后，检查认知能力和未来VaD诊断之间的关联强度。（大于或等于75）在6年的时间内进行了3次整体认知功能测试（简易精神状态检查[MMSE]）。研究样本在前2次测量时未出现痴呆。在最后一次，22人被诊断为VaD，和450人仍然nondemential. Results-preclinical VaD组显示没有MMSE缺陷6年前诊断（P>0.10）与对照组相比。然而，诊断前3年，在控制人口统计学因素和既往血管疾病后，认知能力差与即将发生的VaD显著相关（优势比，2.55; 95%可信区间，1.67至3.89）。结论-这项研究扩展了以前关于VaD临床前认知缺陷的发现，并表明认知测量在识别有风险的个体的过程中是有用的。发展VaD以开始早期治疗。
Background and Purpose-Recent studies have shown that cognitive deficits are present during the years preceding a diagnosis of vascular dementia (VaD). The aims of this study were to (1) extend previous research by examining whether cognitive deficits are already present 6 years before diagnosis, and (2) examine the strength of the association between cognitive performance and a future VaD diagnosis after controlling for previous vascular disorders.Methods-Subjects from a population-based study of very old persons (greater than or equal to75) were examined with a test of global cognitive functioning (the Mini-Mental State Examination [MMSE]) at 3 occasions over a 6-year period. The study sample was nondemented the first 2 measurement times. On the last occasion, 22 individuals were diagnosed with VaD, and 450 persons remained nondemented.Results-The preclinical VaD group showed no MMSE deficits 6 years before diagnosis (P>0.10) compared with the controls. However, 3 years before diagnosis, poor cognitive performance was significantly associated with forthcoming VaD after controlling for demographic factors and prior vascular disorders ( odds ratio, 2.55; 95% CI, 1.67 to 3.89).Conclusions-This study extends previous findings on preclinical cognitive deficits in VaD and suggests that cognitive measures can be useful in the process of recognizing individuals at risk for developing VaD to initiate early treatment.