Rat somatosensory (SmI) cortex: I. Characteristics of neuronal responses to noxious stimulation and comparison with responses to non-noxious stimulation
Rat somatosensory (SmI) cortex: I. Characteristics of neuronal responses to noxious stimulation and comparison with responses to non-noxious stimulation
复制标题
大鼠体感（SmI）皮层：一、神经元对伤害性刺激的反应特征及其与非伤害性刺激反应的比较
DOI：
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发表时间：
2004
影响因子：
2
通讯作者：
G. Guilbaud
中科院分区：
文献类型：
--
作者：
Y. Lamour;J. Willer;G. Guilbaud
摘要研究了氟烷-一氧化二氮麻醉下大鼠体感（SmI）皮质对有害和非有害躯体刺激的单个单位反应。观察到四类神经元：（1）由非伤害性皮肤刺激驱动的神经元，（2）由非伤害性深部刺激驱动的神经元，（3）仅由伤害性刺激驱动的神经元（伤害性特异性神经元），（4）由伤害性和非伤害性刺激驱动的神经元（会聚或伤害性非特异性神经元）。对侧皮肤非伤害性刺激所驱动的神经元感受野较小。在大多数情况下，这些神经元对皮肤刺激有阶段性反应。刺激深层感受器（例如关节运动）驱动的神经元也可以记录在SmI皮层的同一部分。神经元驱动的伤害性刺激有大的感受野，往往是紧张性驱动的伤害性刺激。会聚（或伤害性非特异性）神经元通常可以从不包括在其兴奋性感受野的身体部位被抑制。一些由伤害性刺激驱动的神经元能够编码刺激参数，例如热水浴的温度或刺激的皮肤区域的表面。在给定的电极穿透期间，可以连续记录上面定义的不同类别的神经元。不同类别的输入的躯体组织的证据。这些结果强烈表明，第一体感（SmI）新皮层参与伤害性感受。
SummarySingle unit responses to noxious and non-noxious somatic stimulation were investigated in the somatosensory (SmI) cortex of rats under halothane-nitrous oxide anaesthesia. Four categories of neurons were observed: (1) neurons driven by non-noxious cutaneous stimulation, (2) neurons driven by non-noxious deep stimulation, (3) neurons driven by noxious stimulation only (nociceptive specific neurons), (4) neurons driven by noxious as well as non-noxious stimulation (convergent or nociceptive non-specific neurons). The receptive fields of the neurons driven by contralateral cutaneous non-noxious stimulation were small. These neurons responded phasically to cutaneous stimulation in the majority of cases. Neurons driven by stimulation of deep receptors (e.g. joint movement) could also be recorded in the same part of SmI cortex. Neurons driven by noxious stimulation had large receptive fields and were often tonically driven by noxious stimulation. Convergent (or nociceptive non-specific) neurons could often be inhibited from body parts not included in their excitatory receptive field. Some neurons driven by noxious stimulation were able to encode stimulus parameters such as temperature of a hot water bath or surface of the skin area stimulated. The different categories of neurons defined above could be successively recorded during a given electrode penetration. Evidence for the somatotopic organization of the different categories of inputs was obtained. These results strongly suggest that the first somatosensory (SmI) neocortex is involved in nociception.
影响因子：
2.5
作者：
KENSHALO, DR;GIESLER, GJ;WILLIS, WD
通讯作者：
WILLIS, WD