Alterations in neuroendocrine function during photoperiod induced testicular atrophy and recrudescence in the golden hamster.
Alterations in neuroendocrine function during photoperiod induced testicular atrophy and recrudescence in the golden hamster.
复制标题
光周期期间神经内分泌功能的改变导致金黄地鼠睾丸萎缩和复发。
DOI：
10.1095/biolreprod26.3.437
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发表时间：
1982
影响因子：
3.6
通讯作者：
Goldman,BD
中科院分区：
文献类型：
--
作者：
Steger,RW;Bartke,A;Goldman,BD
金黄色（叙利亚）仓鼠从14 L：10 D（光：暗）到5 L：19 D光周期的转移导致生殖轴发生深刻变化。睾丸重量在短光周期暴露后7周内下降，并保持较低水平，直到19周，此时开始自发复发。暴露7.5周时，血浆LH、FSH和Prl水平检测不到，但LH和FSH在15周时恢复至基础水平，Prl在20.5周时恢复至基础水平。下丘脑LHRH水平增加，同时LH和FSH的下降，表明LHRH释放减少。血浆促性腺激素水平升高和睾丸复发与下丘脑LHRH含量降低相关。10周时下丘脑去甲肾上腺素（NE）周转率较低，表明LH和FSH水平降低最终是由于肾上腺素能活性降低。在15周时，血浆LH水平和下丘脑NE周转均高于10周时观察到的值。下丘脑多巴胺营业额，可能反映了减少PRL反馈，0和10周之间下降，但15周恢复到对照水平。因此，似乎与光周期诱导的睾丸退化和复发相关的内分泌变化继发于下丘脑功能的变化。
Transfer of golden (Syrian) hamsters from a 14L:10D (Light:dark) to a 5L:19D photoperiod causes profound changes in the reproductive axis. Testicular weight fell within 7 weeks of short photoperiod exposure and remained low until 19 weeks, at which time spontaneous recrudescence began. Plasma LH, FSH, and Prl levels were undetectable at 7.5 weeks of exposure, but LH and FSH returned to basal levels by 15 weeks and Prl by 20.5 weeks. Hypothalamic LHRH levels increased concurrently with the fall in LH and FSH, suggesting that LHRH release was decreased. Increasing plasma gonadotropin levels and testicular recrudescence were associated with decreases in hypothalamic LHRH content. Hypothalamic norepinephrine (NE) turnover was low at 10 weeks, suggesting that decreased LH and FSH levels were ultimately due to decreased adrenergic activity. At 15 weeks, plasma LH levels and hypothalamic NE turnover were both increased over values seen at 10 weeks. Hypothalamic dopamine turnover, possibly reflecting decreased Prl feedback, was decreased between 0 and 10 weeks, but returned to control level by 15 weeks. It, therefore, appears that the endocrine changes associated with photoperiod induced testicular regression and recrudescence are secondary to changes in hypothalamic function.